Table 4 Adverse Events Related to Ezatiostat in Combination with Lenalidomide for Both Dose Groups Combined
NCI-CTCAE v3.0 Maximum Toxicity Grade (N = 19) | |||||
|---|---|---|---|---|---|
Adverse Event (Preferred Term) | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Total |
n (%) | n (%) | n (%) | n (%) | n (%) | |
Hematologic (All Patients) | |||||
Thrombocytopenia | 1 (5) | 1 (5) | 4 (21) | 3 (16) | 9 (47) |
Neutropenia | 0 | 2 (11) | 2 (11) | 2 (11) | 6 (32) |
Anemia | 0 | 0 | 3 (16) | 1 (5) | 4 (21) |
Febrile Neutropenia | 0 | 0 | 2 (11) | 0 | 2 (11) |
Non-Hematologic (≥ 5% of Patients) | |||||
Diarrhoea | 5 (26) | 3 (16) | 3 (16) | 0 | 11 (58) |
Nausea | 7 (37) | 3 (16) | 1 (5) | 0 | 11 (58) |
Vomiting | 6 (32) | 4 (21) | 1 (5) | 0 | 11 (58) |
Fatigue | 1 (5) | 5 (26) | 0 | 0 | 6 (32) |
Skin Odour Abnormal | 3 (16) | 1 (5) | 0 | 0 | 4 (21) |
Abdominal Pain Upper | 2 (11) | 1 (5) | 0 | 0 | 3 (16) |
Anorexia | 2 (11) | 1 (5) | 0 | 0 | 3 (16) |
Rash | 0 | 1 (5) | 2 (11) | 0 | 3 (16) |
Constipation | 2 (11) | 0 | 0 | 0 | 2 (11) |
Flatulence | 1 (5) | 1 (5) | 0 | 0 | 2 (11) |
Muscle Spasms | 1 (5) | 0 | 1 (5) | 0 | 2 (11) |
Muscular Weakness | 0 | 1 (5) | 1 (5) | 0 | 2 (11) |
Oedema Peripheral | 1 (5) | 1 (5) | 0 | 0 | 2 (11) |