From: Validation of the M. D. Anderson Symptom Inventory multiple myeloma module
Stable/improving ECOG PS (n= 60) | Worsening ECOG PS (n= 66) | Difference | Effect size | |||
---|---|---|---|---|---|---|
Meana | SD | Meana | SD | |||
Change in composite scores | ||||||
Core subscale | 0.07 | 1.54 | 1.66 | 1.62 | 1.59b | 0.90 |
Severity subscale | 0.09 | 1.35 | 1.52 | 1.42 | 1.43b | 0.91 |
Interference subscale | 0.16 | 2.63 | 2.15 | 2.38 | 1.99b | 0.74 |
Change in MDASI-MM items | ||||||
Dry mouth | −0.92 | 3.49 | 3.44 | 3.33 | 4.36b | 1.08 |
Fatigue | −0.28 | 3.11 | 2.44 | 2.68 | 2.72b | 0.85 |
Lack of appetite | 0.70 | 3.09 | 3.85 | 3.62 | 3.15b | 0.85 |
Nausea | 0.68 | 2.25 | 3.48 | 3.60 | 2.80b | 0.84 |
Drowsiness | −0.52 | 3.92 | 2.23 | 2.92 | 2.75b | 0.74 |
Diarrhea | 1.15 | 3.01 | 3.68 | 3.67 | 2.53b | 0.71 |
Vomiting | 0.40 | 1.43 | 1.89 | 3.10 | 1.49c | 0.59 |
Mouth/throat sores | 0.37 | 2.18 | 1.86 | 3.41 | 1.49c | 0.50 |
Pain | −0.48 | 3.35 | 1.15 | 3.09 | 1.63c | 0.49 |
Muscle weakness | 0.42 | 3.29 | 1.83 | 2.52 | 1.41c | 0.47 |
Numbness | 0.90 | 2.70 | −0.24 | 2.21 | −1.14c | 0.45 |
Disturbed sleep | 0.02 | 3.41 | 1.20 | 3.21 | 1.18c | 0.35 |
Bone aches | −1.03 | 3.59 | 0.13 | 3.17 | 1.16c | 0.34 |
Shortness of breath | −0.08 | 2.23 | 0.68 | 2.23 | 0.76 | 0.34 |
Sadness | −0.02 | 2.00 | 0.55 | 2.77 | 0.57 | 0.23 |
Difficulty paying attention | 0.25 | 1.87 | 0.65 | 2.12 | 0.40 | 0.20 |
Difficulty remembering | 0.02 | 1.78 | 0.27 | 1.62 | 0.25 | 0.15 |
Constipation | −0.50 | 2.94 | −0.20 | 2.24 | 0.30 | 0.11 |
Distress | 0.52 | 2.66 | 0.68 | 2.97 | 0.16 | 0.06 |
Rash | 0.32 | 1.58 | 0.34 | 2.16 | 0.02 | 0.01 |