Acute dyspnoea and single tracheal localisation of mantle cell lymphoma
© Ianotto et al; licensee BioMed Central Ltd. 2010
Received: 26 July 2010
Accepted: 28 September 2010
Published: 28 September 2010
Mantle cell lymphoma is a lymphoid entity characterized by adenopathy, blood and bone marrow involment which only recurrent mucosal localisation is the lymphomatoid polyposis. Few other mucosal infiltrations have been already reported.
We report here the first case of a unique tracheal localisation of mantle cell lymphoma at presentation of the disease. The presence of classical t(11;14)(q13;q32) confirmed the diagnosis of mantle cell lymphoma by eliminating MALT or cancer localisation.
This case illustrates the necessity to ensure the diagnosis of mucosal lymphoma versus MCL since these diseases need different treatment regimens and prognoses.
To the Editor,
Mantle cell lymphoma is a lymphoid entity defined by clinical, cytological, immunological, biochemical and cytogenetic criteria . One particular entity of MCL, lymphomatoid polyposis, is characterised by the involvement of the gastrointestinal tract (30%), distinct from a mucosal associated lymphoid tissue (MALT) localisation [2, 3]. The frequency of MALT in the trachea is very low; however, nasopharynx and Waldeyer's ring localisations of MCL mimicking MALT have been reported [4, 5]. Dyspnoea was previously described in mediastinal involvement of MCL compressing the trachea . Two cases have been already reported but there were relapse site or one of the multiple localisation of the MCL [7, 8]. This case is different because of its unique localisation and the fact that it is the first evolution of the disease. Because tracheal involment is most seen in cancer and MALT lymphoma with different therapy and evolution, it is important to maximise the chance of an accurate diagnosis by correlating anatomo-pathologist and cytogenetic exams so as not to underestimate the incidence of atypical MCL in cancer/MALT localisation. This case illustrates the necessity to ensure the diagnosis of mucosal lymphoma versus MCL since these diseases have different treatment regimens and prognoses.
Mucosal Associated Lymphoid Tissue
Mantle Cell Lymphoma.
- Campo E, Raffeld M, Jaffe ES: Mantle-cell lymphoma. Seminars in Hematology. 1999, 36: 115-127.PubMedGoogle Scholar
- Rao DS, Said JW: Small lymphoid proliferations in extranodal locations. Archives of Pathology and Laboratory Medicine. 2007, 131: 383-396.PubMedGoogle Scholar
- Okubo K, Miyamoto N, Komaki C: Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the trachea: a case of surgical resection and long term survival. Thorax. 2005, 60: 82-83. 10.1136/thx.2003.018721.PubMed CentralView ArticlePubMedGoogle Scholar
- Zinzani PL, Magagnoli M, Galieni P, Martelli M, Poletti V, Zaja F, Molica S, Zaccaria A, Cantonetti AM, Gentilini P, Guardigni L, Gherlinzoni F, Ribersani M, Bendandi M, Albertini P, Tura S: Nongastrointestinal low-grade mucosa-associated lymphoid tissue lymphoma: analysis of 75 patients. Journal of Clinical Oncology. 1999, 17: 1254-PubMedGoogle Scholar
- Jaffe ES: Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis. Modern Pathology. 2002, 15: 255-263. 10.1038/modpathol.3880521.View ArticlePubMedGoogle Scholar
- Amemiya M, Takise A, Kaira K, Endou K, Horie T, Inazawa M: Obstructive sleep apnea syndrome in a patient with superior vena cava syndrome caused by malignant lymphoma. Nihon Kokyuki Gakkai Zasshi. 2006, 44: 197-201.PubMedGoogle Scholar
- Kuppusamy Gounder S, Sikder M, Srinivas S, Chang VT, Kasimis B: Asymptomatic mantle cell lymphoma in the trachea. Leukemia Lymphoma. 2009, 50: 651-652. 10.1080/10428190902718818.View ArticlePubMedGoogle Scholar
- Verde F, McGeehan A: Endotracheal involvement as an unusual extranodal site of recurrence from mantle cell lymphoma. Radiolology Case Report. 2008, 3: 194-OnlineGoogle Scholar
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