Diagnosis and treatment of viral diseases in recipients of allogeneic hematopoietic stem cell transplantation
© Lin and Liu; licensee BioMed Central Ltd. 2013
Received: 26 October 2013
Accepted: 30 November 2013
Published: 17 December 2013
Viral infections are important causes of morbidity and mortality after allogeneic stem cell hematopoietic transplantation (allo-HSCT). Although most viral infections present with asymptomatic or subclinical manifestations, viruses may result in fatal complications in severe immunocompromised recipients. Reactivation of latent viruses, such as herpesviruses, is frequent during the immunosuppression that occurs with allo-HSCT. Viruses acquired from community, such as the respiratory and gastrointestinal viruses, are also important pathogens of post-transplant viral diseases. Currently, molecular diagnostic methods have replaced or supplemented traditional methods, such as viral culture and antigen detection, in diagnosis of viral infections. The utilization of polymerase chain reaction facilitates the early diagnosis. In view of lacking efficacious agents for treatment of viral diseases, prevention of viral infections is extremely valuable. Application of prophylactic strategies including preemptive therapy reduces viral infections and diseases. Adoptive cellular therapy for restoring virus-specific immunity is a promising method in the treatment of viral diseases.
KeywordsViral infection Allogeneic hematopoietic stem cell transplantation Diagnosis Treatment Prevention
Viral infections are common complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). With wide use of HLA-mismatch, unrelated and cord blood donors as alternative sources of hematopoietic stem cells, and anti-thymocyte globulin (ATG) as the standard prophylaxis of graft versus host disease (GVHD) in HLA-mismatch and unrelated donor transplantation, allo-HSCT recipients are at increasing risk for viral infections [1–5]. Fortunately, improvements in viral diagnostics, such as utilization of polymerase chain reaction (PCR)-based molecular diagnostic methods as replacement of traditional methods, facilitate the early diagnosis of viral infections [6–8]. And application of prophylactic and preemptive strategies limits the reactivation of latent viruses and development of viral diseases [9–11]. Immunotherapeutic strategies to restore virus-specific immunity, such as virus-specific cytotoxic T cells (CTL) and donor lymphocyte infusion (DLI), have been used for the treatment of viral diseases [12–14]. These developments improve outcomes of viral infections after allo-HSCT [15–17]. The aim of this article is to review the current concepts of diagnosis, prevention and treatment of viral diseases in the recipients of allo-HSCT. A brief overview will be followed by a detailed discussion on common viral diseases and viruses.
In the recipients of allo-HSCT, the difference in the reported incidence is due in part to asymptomatic or subclinical manifestations in most of viral infections and the changing epidemiology of viruses as well as differences in diagnostic methods [18–23]. Till now, large-sampled epidemiological data on overall incidence of viral infections are absent in the recipients of allo-HSCT. The limited data show that community acquired respiratory viruses (CARVs) and herpesviruses are the most common pathogens [24–26]. Among the causes of CARVs respiratory tract infections, a preponderance of respiratory syncytial virus (RSV) and parainfluenza virus (PIV) are reported, followed by influenza virus and human metapneumovirus (HMPV) [19, 20, 27]. In herpesvirus family, the incidence of herpes simplex virus (HSV) and varicella zoster virus (VZV) infections as well as cytomegalovirus (CMV) diseases have significantly decreased because of the effective prophylaxis [24, 25]. The reports on human herpes virus (HHV)-6 diseases are increasing in allo-HSCT recipients [28–32].
Risk factors for viral infections
In the recipients of allo-HSCT, most viral infections are opportunistic and closely related with immune status. Thus, factors influencing engraftment and immune reconstitution all potentially impact viral infections. Peripheral blood stem cell transplantation is associated with fewer viral infections than bone marrow and cord blood transplantation due to better hematopoietic and immune reconstitution [33–35]. Compared with HLA-match related transplantation, HLA-mismatch related and unrelated transplantation have an increasing risk of viral infections because immune reconstitution is delayed by the intensified GVHD prophylactic strategy, such as the use of ATG [18, 36–38]. GVHD may delay immune reconstitution and is considered an independent risk factor of viral infections . In addition, other factors, such as the serologic status of donors and recipients before transplantation as well as the age of recipients, may also affect the incidence of viral infections. For example, CMV-seronegative recipients receiving graft from CMV-seropositive donors are at high risk of CMV diseases . Children are high-risk population of CARVs infections .
Generally, the diagnosis of viral diseases in immunocompetent individuals is based on clinical manifestations and laboratory examination. A definitive diagnosis requires detection of specific virus in specimens obtained from involved tissues and secretions as well as blood, or even histopathologic evidences. However, such a definitive diagnosis is frequently unnecessary or unavailable due to the risk associated with the invasive procedure (e.g. infection, bleeding) [25, 39]. Thus, stratified diagnosis of viral infections and diseases based on diagnostic evidences is recommended [25, 39]. The clinical manifestations of viral diseases in immunocompromised individuals, including transplant recipients may be different with the immunocompetent population . For instance, fever does not always occur and the disseminated diseases are more common [24, 25, 39]. Meanwhile, viral diseases generally occur with or subsequently to other transplant complications such as bacterial and fungal infections [24, 25]. For example, CMV gastrointestinal disease is particularly difficult to diagnose because it frequently presents together with gut GVHD, and diarrhea is the same symptom of these two transplant complications . Therefore, in the recipients of allo-HSCT, the diagnosis of viral diseases mainly depends on laboratory examination.
Common methods used in diagnosis of viral infections after transplantation
HSV, CMV, VZV, Influenza virus, RSV, PIV, adenovirus
May take weeks before results return
Shell vial culture
HSV, CMV, VZV, Influenza virus, RSV, PIV, adenovirus
Reduce the testing time compared with culture
Most CARVs, herpesviruses, adenovirus
All are possible
Histopathology and immunohistochemistry
All are possible
Detect viruses in tissue
All are possible
Require facility and experienced staff
Less helpful in diagnosis
Although multiple strategies have been used [17, 24–26, 39], the treatment of viral diseases remains rather a challenge because few agents are available and efficacious. In the recipients of allo-HSCT, immunotherapeutic strategies to restore virus-specific immunity, such as reducing immunosuppressants, DLI and ex vivo generation of virus-specific CTL, are now advocated in the treatment of viral diseases [14, 25, 49]. However, reducing immunosuppressants is unfeasible in many patients due to potential risk of GVHD [24, 25], and DLI is limited by unavailable stem cell donors and the risk of exacerbating GVHD . Of note, these adoptive cellular therapies are only proven efficacious for a few viruses, such as CMV, EBV and adenovirus [12, 50, 51]. Early intervention has a dramatic influence upon survival and may reduce the extent of permanent injury in survivors [20, 52, 53]. For example, in patients with CARVs infections, treatment is more effective if started prior to development of lower respiratory tract infection (LRTI) or respiratory failure [26, 54, 55]. Our data showed that the patients with EBV fever without tissue involvement had better treatment response than those with end-organ diseases or PTLD .
Since specific therapy is limited to only several antiviral agents, prevention of viral infections is crucial to reduce the incidence and mortality of viral diseases. According to the different periods of transplantation, the strategies might be divided to prophylaxis pre-transplantation, during transplantation and post-transplantation. Before transplantation, selection of virus-seronegative stem cell donors for seronegative recipients, and decreasing virus loads in virus-seropositive donors and recipients should be considered. During transplantation, the strategies of conditioning and GVHD prophylaxis should be chosen prudently to minimize the delay of immune reconstitution. After transplantation, prophylaxis should be performed throughout the risk period such as pre-engraftment and GVHD. The incidence of HSV and VZV infections has decreased from 80% to lower than 5% in the recipients of allo-HSCT receiving antiviral prophylaxis throughout the risk period [25, 56]. Preemptive therapy for reactivation of some latent viruses, such as CMV and EBV has been demonstrated to reduce the progression of viral diseases [24, 25]. Vaccination, such as Measles–Mumps–Rubella and VZV vaccine, seems useful to prevent corresponding viral infections [57, 58]. Influenza virus vaccine is suggested to be given to the recipients prior to each influenza season .
Viral diseases after HSCT
Respiratory diseases after HSCT are mainly caused by CARVs [60, 61]. Other viruses, such as herpesviruses and adenovirus, may also result in respiratory infections [61, 62]. Majority of the patients present with upper respiratory infection, and 18-44% of these patients may progress to lower respiratory infection with mortality of 23-50% [18–21, 23, 63]. The incidence of respiratory diseases after allo-HSCT ranges from 3.5% to 29% [20, 64], and the incidence of viral pneumonia is 2.1-14% [4, 20, 64–66]. Typical clinical manifestations include fever, cough, myalgias. Dyspnea is an important symptom of viral pneumonia. Some of CARVs infections show a pronounced seasonality. For example, RSV and influenza virus reach a peak incidence during the winter and spring . CARVs may also result in epidemic outbreak in the wards. Herpesvirus pneumonia is usually caused by reactivation of latent viruses which occurs in severe immunosuppression such as early period of transplantation and GVHD [2, 67, 68].
In immunocompetent individuals, herpesviruses are the most frequent pathogens in sporadic viral encephalitis/meningitis. A retrospective study from Schmidt-Hieber et al. showed that viral encephalitis was mainly caused by human herpes virus (HHV) -6, followed by EBV, HSV, JC virus, CMV, VZV in the recipients of allo-HSCT . Our data showed that herpesvirus-associated encephalitis was mainly caused by EBV followed by HSV, CMV and VZV . Recently, encephalitis caused by adenovirus is increasing . The incidence of viral encephalitis after allo-HSCT was 1.2% in a retrospective study . Our results revealed that the incidence of herpesviruses-associated encephalitis/meningitis was 6.3% . In the recipients of allo-HSCT, viral encephalitis/ meningitis usually occurs within 100 days post-transplantation. Clinical manifestations of viral encephalitis/ meningitis are diverse, including fever, changes of consciousness, seizures, palsy of brain nerves and psychiatric disorders; but meningeal irritation is not common compared with healthy population . The mortality of viral encephalitis/ meningitis ranges from 0% to 80%, depending on virus types and timing of diagnosis and treatment [69, 71].
Rotavirus and norovirus are considered main causes of viral gastroenteritis. Currently, adenovirus and CMV are increasingly recognized as important pathogens of viral gastroenteritis in the recipients of allo-HSCT. Astrovirus-associated gastroenteritis which usually occurs in children is rarely observed in the recipients of allo-HSCT . Few data are available on the incidence of viral gastroenteritis after allo-HSCT. Van Kraaij et al. documented that 19% of HSCT recipients (including allo- and auto-HSCT) developed viral gastroenteritis . Fortunately, the mortality caused by rotavirus and norovirus-related gastroenteritis is rare [74–77]. The most common clinical manifestation of viral gastroenteritis is diarrhea, followed by vomiting and nausea. Rotavirus and norovirus infections are seasonal with a peak incidence in winter. Most of the patients acquire the viruses from community [74, 77]. The median onset time of adenovirus and CMV gastroenteritis are 60–90 days after transplantation, and usually associated with acute GVHD [76, 78].
Viral hepatitis is the third cause of hepatic impairment in the recipients of allo-HSCT, and usually occurs in 3–6 months after transplantation . The most frequent pathogens of viral hepatitis are hepatitis B virus (HBV) and hepatitis C virus (HCV) [80, 81]. Besides, other viruses such as CMV and HSV may also result in hepatitis [24, 25]. Hepatitis B and C can be caused by either virus reactivation or blood transmission. Since the carriage rates of HBV and HCV vary in different regions, the incidence of viral hepatitis varies [81, 82]. Increasing virus loads in blood is valuable for diagnosis. Of note, the diagnosis of viral hepatitis should be based on exclusion of other transplant complications (e.g., sinusoidal obstruction syndrome [SOS] and GVHD). Attributed to effective prophylaxis and antiviral treatment, the mortality of hepatitis B and C is low [81, 83].
Post-transplant cystitis usually present with hemorrhagic cystitis (HC). According to onset time, HC is divided into early-onset HC (within 48 hours of conditioning) and late-onset HC (occurring after 48 hours). Early-onset HC is often due to the toxicity of conditioning regimen such as cyclophosphamide. It is reported that 11.6-42% of patients develop late-onset HC after transplantation [84, 85]. Late-onset HC was considered to be related with reactivation of latent BK virus (BKV), but this association remains controversial [86, 87]. Some studies suggested that acute GVHD might increase the risk of HC [87, 88]. Recently, adenovirus and CMV were suggested to be associated with late-onset HC [88, 89].
PTLD is a life-threatening complication following allo-HSCT. Approximately 90% of PTLD result from EBV-driven B cell proliferation poorly controlled by a weakened immune response. Recent data implicated that CMV and HHV-6 might contribute to the development of PTLD [90, 91]. The incidence of PTLD varies from 0.5% to 22%, depending on the number of risk factors [3, 68, 92–94]. In the recipients of allo-HSCT, most of PTLD occur within 1 year post-transplantation, reaching a peak incidence within 3 months [95–97]. Isolated nodal involvement is the most common presentation. About 20% of patients present with extranodal involvement, and isolated extranodal involvement is not rare [93, 96, 98–100]. Clinical presentations of PTLD depend on location and the degree of organ involvement. PTLD with extranodal involvement usually have poor outcome. The mortality of PTLD is 50-64% [68, 94]. Delay of diagnosis and treatment is associated with a high mortality (>90%) [96, 101].
Other viral diseases
Bone marrow suppression is common in the recipients of allo-HSCT. Graft failure is a fatal complication after transplantation. Several viruses, such as CMV, EBV, HHV-6 and adenovirus have been recognized the causes of bone marrow suppression and graft failure [24, 25, 39, 102]. The diagnosis of virus-associated graft failure should be based on pancytopenia, bone marrow hypoplasia, detection of virus together with exclusion of GVHD, rejection and relapse  .
Common viruses in allo-HSCT recipients
Laboratory diagnosis of herpesviruses
Up to 80% of the healthy population have history of HSV-1 and −2 infections . HSV-1 infection is more common than HSV-2. After primary infection, the virus becomes latent in the neuronal cells. Historically, 80% of HSV-seropositive patient developed reactivation after allo-HSCT without antiviral prophylaxis . Fortunately, the incidence of HSV reactivation has now decreased to 0-3% because of prophylactic acyclovir [56, 105]. HSV causes a spectrum of diseases, such as herpes, oesophagitis, bone marrow suppression, respiratory tract diseases, hepatitis and encephalitis in the recipients of allo-HSCT . Due to the high rate of HSV reactivation, prophylactic oral acyclovir has been administered routinely in allo-HSCT recipients. Intravenous acyclovir should be considered for patients with poor drug absorption [17, 106]. Valacyclovir is an alternative prophylactic agent with good bioavailability [107–109]. Acyclovir is recommended as the therapy for severe mucocutaneous or visceral HSV disease in transplant recipients . Valaciclovir and famciclovir are considered as alternatives for less serious manifestations of HSV diseases . The recommended drug for acyclovir-resistant HSV is foscarnet . Cidofovir might be effective to treat HSV infection which is resistant to both acyclovir and foscarnet .
Varicella caused by primary VZV infection is a common childhood disease. After primary infection, VZV establishes latency in the dorsal root ganglia in immunocompetent host. The reactivation of VZV results in herpes zoster [111, 112]. In the recipients of allo-HSCT, VZV is also an important cause of viral encephalitis. VZV immunization is advocated in recipients without a history of varicella. Varicella vaccine has been showed to be safe in children with leukemia, but few data are available in transplant recipients . Besides, vaccination of VZV-seronegative individuals who may be in contact with the patients during transplantation should be done . Zoster immune globulin (ZIG) and varicella-zoster immune globulin (VZIG) are passive antibody prophylaxis in seronegative recipients after exposure to varicella . Acyclovir and valacyclovir prophylaxis were proven effective in several trials [9, 114–117]. Antiviral therapy with acyclovir is recommended in the treatment of VZV infection . Acyclovir has been shown to reduce the progression and dissemination of VZV infection [118, 119]. Treatment with brivudin or famiciclovir is effective in immunocompromised population [120, 121]. Foscarnet and cidofovir are alternative agents against acyclovir-resistant VZV infection .
CMV infects 70-80% of the healthy individuals and establishes latency in peripheral blood monocytes and tissue macrophages. Till now, CMV remains one of the most important viruses and causes of death in the recipients of allo-HSCT. CMV-associated end-organ diseases include pneumonia, enteritis, hepatitis, retinitis and encephalitis, and so on; CMV syndrome is defined as CMV-associated fever without sign of CMV end-organ disease . Majority of CMV infections are caused by reactivation of virus which usually occurs within 3 months post-transplantation [8, 24, 78]. Approximately 75% of CMV-seropositive recipients develop CMV reactivation, and 20-30% of these patients develop CMV disease without intervention [17, 24]. Preemptive therapy based on CMV antigenemia or DNA-emia significantly reduces the development of CMV disease in allo-HSCT patients [24, 123]. However, the mortality of CMV disease is more than 50% even with treatments [67, 124]. The diagnosis of CMV infection includes CMV viremia, CMV syndrome and CMV end-organ disease . Historically, CMV antigen (pp65) detection was widely used in diagnosis of CMV infection. Recently, PCR is replacing antigenemia assay to be the preferred diagnostic method due to higher sensitivity [24, 103].
Preemptive therapy based on CMV viremia has become the standard prevention of CMV diseases after transplantation . The first-line preemptive therapy is ganciclovir with a minimum duration of 2 weeks depending on whether CMV is detected at the end of the course [24, 125, 126]. The main side effect of ganciclovir is bone marrow suppression which results in the increase of bacterial and fungal infection [127, 128]. Valganciclovir is an alternative with good bioavailability [129–131]. Foscarnet and cidofovir are the second-line prophylactic agents considering of drug-associated toxicity .
Ganciclovir is the first-line treatment of CMV diseases. The recommended therapy of CMV pneumonia is a combination of intravenous ganciclovir and high dose immune globulin [24, 124, 132]. In view of toxicity and effective rate, cidofovir and foscarnet are used as second-line therapy of CMV diseases . Ganciclovir resistance is uncommon and usually mediated through mutations in the UL97 gene. Cidofovir is used in the treatment of CMV disease which is resistant to ganciclovir and foscarnet, with an effective rate of 50% . Since it has been known that specific immune response to CMV is important to control reactivation, CMV-specific CTL has been used in prophylaxis and treatment of CMV viremia in several studies [50, 51, 134]. Leen et al. reported that the response rate of CMV-specific CTL was 73.9% in the treatment of CMV diseases after allo-HSCT .
Approximately 90% of healthy adults have been infected by EBV. After primary infection, EBV is latent in B cells (6, 8). Primary EBV infection or reactivation usually induces asymptomatic infection or infectious mononucleosis in immunocompetent people. However, EBV results in a spectrum of diseases in the recipients of allo-HSCT, ranging from fever, end-organ disease (pneumonia, encephalitis/myelitis, and hepatitis) to PTLD . Among these diseases, PTLD is most common [4, 25]. Our data showed that the 3-year cumulative incidence of EBV disease were 15.6% in the recipients of allo-HSCT, with the PTLD incidence of 9.9% . EBV disease is usually caused by reactivation of latent virus after allo-HSCT. After transplantation, 14-65% of recipients developed EBV reactivation, depending on different risk factors that the recipients have [37, 68, 135]. The diagnosis of EBV infection includes EBV viremia, probable end-organ disease and proven end-organ disease as well as PTLD .
Since rapid increase of EBV-DNA loads in blood is considered to be related with subsequent EBV diseases , routine monitoring of EBV viral loads is necessary after transplantation . Preemptive therapy based on EBV-DNA loads in blood and risk factors for EBV disease has yielded good results . Preemptive therapy is now developing mainly in two directions: adoptive cellular therapy (EBV-specific CTL) and B-cell depletion with monoclonal antibodies. EBV-specific CTL has been demonstrated effective to prevent EBV disease in several studies [135, 137], but the production of CTL requires time. Besides, reduction of immunosuppressants is an ideal preemptive therapy, but frequently not available due to the risk of GVHD. Rituximab is easily available and has shown little toxicity . Based on the above, rituximab is recommended as the preferred preemptive therapy, followed by reduction of immunosuppresants and EBV-specific CTL in the European guidelines .
The therapeutic strategies of EBV disease include anti-virus, restoration of T cell response and clearance of the EBV infected cells. Antiviral agents (e.g. acyclovir and ganciclovir) can reduce EBV replication, but is not active in PTLD presumably because that viral thymidine kinase expression is low during lytic phase and lack during latency [139, 140]. Recently, a novel agent arginine butyrate, which induces EBV thymidine kinase transcription, has been shown in vitro to render latently infected EBV-immortalized B cells susceptible to ganciclovir [139, 140]. Treatments to restore T-cell reactivity include reduction of immunosuppressants and adoptive cellular therapy (CTL and DLI) . Anti-CD20 monoclonal antibody (rituximab) is used to clear EBV-infected B cells .
According to the European guidelines, rituximab is a recommendation of highest priority for treatment of PTLD; other first-line treatment includes reducing immunosuppressants, EBV-CTL and DLI . Chemotherapy is recommended as the second-line therapy . The response rate of rituximab monotherapy was reported 44-69% whereas the relapse rate was 18-32% [141–144]. Compared with rituximab, adoptive cellular immunotherapy has higher response rate (50-88%) and fewer relapse (0%) [12, 145, 146]. Nevertheless, the utilization of adoptive cellular therapy is limited by the aforementioned disadvantages such as time and facilities required by CTL production as well as potential risk of GVHD caused by DLI [12, 14, 97, 137, 145]. Chemotherapy is reported to induce remissions in 40-50% of the PTLD patients but with significant treatment-related mortality and relapse rate [141, 147]. Therefore, in the ‘era of rituximab’, chemotherapy is barely used unless for CD20-negative PTLD or combination with rituximab . To date, there are no randomized trials to compare the efficacy between rituximab alone and rituximab combined with chemotherapy. Trappe et al.  suggested that sequential first-line treatment with rituximab followed by chemotherapy is more efficacious than first-line rituximab monotherapy followed by chemotherapy at progression or relapse. In our study, we introduced a sequential therapeutic strategy that is rituximab-based treatments followed by adoptive cellular immunotherapy. The results revealed that this strategy might elevate response rate and decrease the relapse rate. Besides, this strategy might overcome the drawback of long time frame to product EBV-CTL and reduce the risk of GVHD caused by DLI. It remains a matter of discussion that whether histology subtypes of PTLD affect the outcome of rituximab-based treatments [148, 149]. The prognosis of PTLD with extranodal or multi-organ involvement is dismal compared with isolated nodal involvement [34, 150]. Some studies suggested that intrathecal rituximab is efficacious against PTLD with CNS involvement [151–153]. Other therapeutic options include local radiotherapy and operation, which is mainly for the patients with significant compression symptoms .
Clinical data on EBV fever and end-organ diseases are quite limited. Rituximab seems efficacious to treat EBV fever, with a response rate of 100% [4, 154]. The treatment strategies of EBV end-organ diseases are similar with PTLD. However, the efficacy of rituximab monotherapy in patients with end-organ diseases seemed poorer than those with PTLD .
Approximately 50% of recipients develop HHV-6 reactivation after transplantation [28, 30]. HHV-6 diseases include encephalitis, interstitial lung disease and delayed engraftment [24, 31]. Two small-sampled studies suggested that ganciclovir might be effective to prevent HHV-6 reactivation in allo-HSCT recipients [155, 156]. However, no widely accepted prophylactic strategy is recommended considering of the drug toxicity and the low incidence of HHV-6 diseases . Both ganciclovir and foscarnet were reported to be effective against HHV-6 diseases .
HHV-7 infection/reactivation is infrequent in the recipients of allo-HSCT, and little information about HHV-7 diseases is available. Therefore, prophylaxis and treatment of HHV-7 infection remain unclear .
HHV-8 is recognized the cause of Kaposi’s sarcoma in human immunodeficiency virus (HIV) infected patients . HHV-8 infection is rare in the recipients of allo-HSCT, and usually results in non-malignant diseases such as hepatitis, bone marrow suppression [159, 160]. Currently, clinical data on prevention and treatment of HHV-8 diseases after allo-HSCT are based on case reports. Cessation of immunosuppressants and foscarnet were used for treatment, and the efficacy requires further study [161, 162].
CARVs infections after HSCT
Incidence of infection
Progression to LRTI
Mortality with LRTI
PCR(preferred); Antigen detection; culture
PCR(preferred); Antigen detection; culture
Up to 75% 
PCR(preferred); Antigen detection; culture
PCR(preferred); Antigen detection;
Infection control is the mainstay of prevention against CARVs disease. Healthcare facilities and infection control measures, including isolation and strict protection measures for healthcare workers and contacts, should be applied to HSCT recipient [26, 168]. Besides, recipients and contacts should adhere to good personal hygiene. Recipients should avoid contact with individuals with CARVs respiratory infections in the hospital and the community [26, 168].
RSV is one of the most common respiratory pathogens in most series including HSCT recipients. Limited data are available on prevention of RSV infection. In some studies, treating upper respiratory tract disease was effective to reduce the progression to pneumonia and improve the outcome [26, 163, 164]. But some other reports did not confirm this result [169, 170]. Aerosolized ribavirin with or without RSV-specific immunoglobulin or intravenous immunoglobulin has been used to treat RSV pneumonia, with the 30-days survival of approximately 60% [19, 54, 64, 163, 171]. Treatment started before respiratory failure is associated with improved outcome [19, 54, 64]. Intravenous ribavirin is less effective but increases the side effects . The efficacy of palivizumab (an RSV-specific monoclonal antibody) in HSCT recipients is not well defined [172, 173].
PIV infection occurs throughout the year, with the highest incidence in July and September . The prophylactic and therapeutic strategies against PIV infection remain a matter of discussion. A large-sampled retrospective analysis suggested that aerosolized ribavirin with or without intravenous immunoglobulin did not improve the outcome of PIV pneumonia . Elizaga et al. documented that the effective rate of aerosolized ribavirin therapy was 100% in the treatment of upper tract infections, whereas only 25% of patients with PIV pneumonia survived .
To prevent influenza after transplantation, the European guidelines recommended that vaccination should be performed in HSCT recipients with seasonal influenza vaccine . Meanwhile, vaccination of healthcare workers and close contacts with HSCT recipients is advocated . Prophylaxis with oseltamivir seems useful after exposure and during the period of influenza circulation [59, 174]. M2 inhibitors, amantadine and rimantidine have no longer been used for treatment due to widespread resistance [175, 176]. Neuraminidase inhibitors (oral oseltamivir or inhalational zanamivir) are now the most widely used therapeutic agents for influenza, with an effective rate of 46-100% [21, 177, 178]. Intervention initiated within 48 hours of symptom onset was associated with reduced risk both for pneumonia and the need for intensive care [21, 179].
At present, respiratory infections after HSCT caused by HCoV, HMPV and HRhV have been increasingly recognized. In our recent study, HCoV was found in 16.2% of the recipients within 6 months after HSCT, including 12% of LRTI; HMPV and HRhV was found in 5.4% and 2.7% of the recipients, respectively. The efficacious prevention and treatment of HMPV infections have not been well described. Ribavirin and/or intravenous immunogloblin were used to treat HMPV pneumonia in several studies but the efficacy was not defined [26, 180]. The prevention and treatment strategies of HRhV are limited by the lack of antiviral agents and clinical trials. There are no recommendations on prophylaxis and treatment due to absence of effective antiviral agents and appropriate clinical studies .
Adenovirus is increasingly recognized as an important pathogen in immunocompromised individuals, especially in the recipients of allo-HSCT. Adenovirus infection may arise from either reactivation of latent virus or acquisition from community. Contrary to self-limited infection in most immunocompetent individuals, adenovirus causes lethal end-organ or systemic diseases in immunocompromised patients . The incidence of adenovirus infection ranges from 0-6% in adult allo-HSCT recipients, and half of these patients developed adenovirus-associated diseases [18, 22]. Adenovirus diseases include respiratory tract disease, gastroenteritis, encephalitis, myocarditis, nephritis and multiple organ involvement [18, 22]. The mortality was reported as high as 100% in adenovirus pneumonia  and 61% in disseminated disease . Now, PCR is the standard diagnostic method of adenovirus infection . Other diagnostic approaches include viral culture and antigen detection .
Strict isolation and hygiene measures are advocated in patients shedding the adenovirus to prevent horizontal transmission and nosocomial outbreaks. Bordigoni et al.  suggested cidofovir or DLI seemed encouraging approaches to prevent adenovirus diseases, whereas ribavirin and vidarabin were ineffective.
The efficacy of ribavirin is controversial in the treatment of adenovirus diseases [182–184]. Several studies documented that cidofovir was efficacious against adenovirus [75, 76, 182, 185]. Considering of the insufficient immune response to control adenovirus reactivation in the patients, adenovirus-specific CTL seems a promising therapy [186, 187]. Leen et al. reported that the effective rate of adenovirus-specific CTL was 77.8% in the recipients of allo-HSCT . In addition, reduction of immunosuppressants is recommended for prophylaxis and treatment if possible .
Rotavirus and norovirus are important pathogens of viral gastroenteritis. The incidence of rotavirus infection is 6.7-11.5% in HSCT recipients, and death is rare [73, 74]. Antigen detection as well as PCR is used in diagnosis of rotavirus infection. At present, norovirus as a cause of gastroenteritis after allo-HSCT is not well recognized . In pediatric HSCT recipients, the incidence of norovirus-associated gastroenteritis was reported 12.9% and no norovirus-associated mortality was observed . Detection of norovirus RNA by PCR is the main diagnostic evidence. Till now, little information is available about prevention and treatment of rotavirus and norovirus in the HSCT population. Oral immunoglobulin and nitazoxanide have been used in some studies .
Among hepatitis viruses, HBV and HCV are important causes of hepatic impairment in the recipients of allo-HSCT. Hepatitis virus-positive donor should be avoided if alternatives exist.
For HBV-negative recipients, pre-transplant vaccination and HBV-specific immune globulin should be considered if the donors are HBV surface antigen positive. For HBV-positive recipients, administration of antiviral agents (i.e. lamivudine, famciclovir, Entecavir and adefovir) pre- and post-transplantation is advocated to reduce HBV replication [189, 190].
Administration of ribavirin and interferon should be considered to decrease or clear the viral loads before transplantation in donors and recipients who are HCV positive [17, 191]. Interferon with or without ribavirin is used for treatment of hepatitis C [192, 193].
JC virus (JVC) which belongs to polyomavirus family is known a pathogen of progressive multifocal leukoencephalopathy (PML) in patients with HIV infection. Reports of PML are quite rare in the recipients of allo-HSCT . Currently, treatment and prevention of JCV in HSCT recipients remain unclear. Treatments consisting of reduction of immunosuppressants, cidofovir and serotonin-reuptake inhibitor as well as of JCV-specific CTL infusion were demonstrated to produce a favorable clinical outcome .
As mentioned, BKV as a member of polyomavirus family is one of the causes of HC in allo-HSCT recipients. It is reported that ciprofloxacin and other fluoroquinolones may be useful to prevent BKV reactivation . Cidofovir has been used in the treatment of BKV-associated HC [196, 197].
Viral diseases are important complications after HSCT. Development of viral diagnostics improves the early diagnosis and increases the diagnostic rate of some newly discovered or uncommon viruses in allo-HSCT recipients. Based on the pathogenesis of viral diseases, prophylaxis, especially preemptive therapy can limit reactivation of some latent viruses. Immunotherapeutic strategies to restore virus-specific immunity are attractive methods in the treatment of viral diseases.
This project was supported by the National High Technology Research and Development Program of China (863 Program) (2011AA020105), the National Natural Science Foundation of China (81270647, 81000231, 81300445) and Project of Guangzhou Science and Technology Plan (11A72121174).
- Gratwohl A, Brand R, Frassoni F, Rocha V, Niederwieser D, Reusser P, Einsele H, Cordonnier C: Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time. Bone Marrow Transplant. 2005, 36 (9): 757-769. 10.1038/sj.bmt.1705140.PubMedView ArticleGoogle Scholar
- Ozdemir E, Saliba RM, Champlin RE, Couriel DR, Giralt SA, de Lima M, Khouri IF, Hosing C, Kornblau SM, Anderlini P: Risk factors associated with late cytomegalovirus reactivation after allogeneic stem cell transplantation for hematological malignancies. Bone Marrow Transplant. 2007, 40 (2): 125-136. 10.1038/sj.bmt.1705699.PubMedView ArticleGoogle Scholar
- Hale G, Waldmann H: Risks of developing Epstein-Barr virus-related lymphoproliferative disorders after T-cell-depleted marrow transplants. CAMPATH Users. Blood. 1998, 91 (8): 3079-3083.PubMedGoogle Scholar
- Xuan L, Jiang X, Sun J, Zhang Y, Huang F, Fan Z, Guo X, Dai M, Liu C, Yu G: Spectrum of Epstein-Barr virus-associated diseases in recipients of allogeneic hematopoietic stem cell transplantation. Transplantation. 2013, 96 (6): 560-566. 10.1097/TP.0b013e31829d38af.PubMedView ArticleGoogle Scholar
- Lv M, Huang XJ: Allogeneic hematopoietic stem cell transplantation in China: where we are and where to go. J Hematol Oncol. 2012, 5: 10-10.1186/1756-8722-5-10.PubMed CentralPubMedView ArticleGoogle Scholar
- Storch GA: Diagnostic virology. Clin Infect Dis. 2000, 31 (3): 739-751. 10.1086/314015.PubMedView ArticleGoogle Scholar
- Watzinger F, Ebner K, Lion T: Detection and monitoring of virus infections by real-time PCR. Mol Aspects Med. 2006, 27 (2–3): 254-298.PubMedView ArticleGoogle Scholar
- Sahin DG, Gunduz E, Kasifoglu N, Akay OM, Us T, Gulbas Z: Cytomegalovirus DNAemia detected with real-time polymerase chain reaction in hematopoietic stem cell transplant patients. Adv Ther. 2013, 30 (8): 784-791. 10.1007/s12325-013-0049-9.PubMedView ArticleGoogle Scholar
- Klein A, Miller KB, Sprague K, DesJardin JA, Snydman DR: A randomized, double-blind, placebo-controlled trial of valacyclovir prophylaxis to prevent zoster recurrence from months 4 to 24 after BMT. Bone Marrow Transplant. 2011, 46 (2): 294-299. 10.1038/bmt.2010.99.PubMedView ArticleGoogle Scholar
- Goodrich JM, Mori M, Gleaves CA, Du Mond C, Cays M, Ebeling DF, Buhles WC, DeArmond B, Meyers JD: Early treatment with ganciclovir to prevent cytomegalovirus disease after allogeneic bone marrow transplantation. N Engl J Med. 1991, 325 (23): 1601-1607. 10.1056/NEJM199112053252303.PubMedView ArticleGoogle Scholar
- Green ML, Leisenring W, Stachel D, Pergam SA, Sandmaier BM, Wald A, Corey L, Boeckh M: Efficacy of a viral load-based, risk-adapted, preemptive treatment strategy for prevention of cytomegalovirus disease after hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012, 18 (11): 1687-1699. 10.1016/j.bbmt.2012.05.015.PubMed CentralPubMedView ArticleGoogle Scholar
- Doubrovina E, Oflaz-Sozmen B, Prockop SE, Kernan NA, Abramson S, Teruya-Feldstein J, Hedvat C, Chou JF, Heller G, Barker JN: Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation. Blood. 2012, 119 (11): 2644-2656. 10.1182/blood-2011-08-371971.PubMed CentralPubMedView ArticleGoogle Scholar
- Mackinnon S, Thomson K, Verfuerth S, Peggs K, Lowdell M: Adoptive cellular therapy for cytomegalovirus infection following allogeneic stem cell transplantation using virus-specific T cells. Blood Cells Mol Dis. 2008, 40 (1): 63-67. 10.1016/j.bcmd.2007.07.003.PubMedView ArticleGoogle Scholar
- Papadopoulos EB, Ladanyi M, Emanuel D, Mackinnon S, Boulad F, Carabasi MH, Castro-Malaspina H, Childs BH, Gillio AP, Small TN: Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation. N Engl J Med. 1994, 330 (17): 1185-1191. 10.1056/NEJM199404283301703.PubMedView ArticleGoogle Scholar
- Ali N, Adil SN, Shaikh MU, Moosajee M, Masood N: Outcome of match related allogeneic stem cell transplantation procedures performed from 2004 till 2011. Exp Hematol Oncol. 2012, 1 (1): 13-10.1186/2162-3619-1-13.PubMed CentralPubMedView ArticleGoogle Scholar
- Loren AW, Porter DL, Stadtmauer EA, Tsai DE: Post-transplant lymphoproliferative disorder: a review. Bone Marrow Transplant. 2003, 31 (3): 145-155. 10.1038/sj.bmt.1703806.PubMedView ArticleGoogle Scholar
- Ljungman P: Prevention and treatment of viral infections in stem cell transplant recipients. Br J Haematol. 2002, 118 (1): 44-57. 10.1046/j.1365-2141.2002.03515.x.PubMedView ArticleGoogle Scholar
- Chakrabarti S, Mautner V, Osman H, Collingham KE, Fegan CD, Klapper PE, Moss PA, Milligan DW: Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood. 2002, 100 (5): 1619-1627. 10.1182/blood-2002-02-0377.PubMedView ArticleGoogle Scholar
- Nichols WG, Gooley T, Boeckh M: Community-acquired respiratory syncytial virus and parainfluenza virus infections after hematopoietic stem cell transplantation: the Fred Hutchinson Cancer Research Center experience. Biol Blood Marrow Transplant. 2001, 7 (Suppl): 11S-15S.PubMedView ArticleGoogle Scholar
- Martino R, Porras RP, Rabella N, Williams JV, Ramila E, Margall N, Labeaga R, Crowe JJ, Coll P, Sierra J: Prospective study of the incidence, clinical features, and outcome of symptomatic upper and lower respiratory tract infections by respiratory viruses in adult recipients of hematopoietic stem cell transplants for hematologic malignancies. Biol Blood Marrow Transplant. 2005, 11 (10): 781-796. 10.1016/j.bbmt.2005.07.007.PubMed CentralPubMedView ArticleGoogle Scholar
- Nichols WG, Guthrie KA, Corey L, Boeckh M: Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy. Clin Infect Dis. 2004, 39 (9): 1300-1306. 10.1086/425004.PubMedView ArticleGoogle Scholar
- Flomenberg P, Babbitt J, Drobyski WR, Ash RC, Carrigan DR, Sedmak GV, McAuliffe T, Camitta B, Horowitz MM, Bunin N: Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis. 1994, 169 (4): 775-781. 10.1093/infdis/169.4.775.PubMedView ArticleGoogle Scholar
- Lewis VA, Champlin R, Englund J, Couch R, Goodrich JM, Rolston K, Przepiorka D, Mirza NQ, Yousuf HM, Luna M: Respiratory disease due to parainfluenza virus in adult bone marrow transplant recipients. Clin Infect Dis. 1996, 23 (5): 1033-1037. 10.1093/clinids/23.5.1033.PubMedView ArticleGoogle Scholar
- Ljungman P, de la Camara R, Cordonnier C, Einsele H, Engelhard D, Reusser P, Styczynski J, Ward K: Management of CMV, HHV-6, HHV-7 and Kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT. Bone Marrow Transplant. 2008, 42 (4): 227-240. 10.1038/bmt.2008.162.PubMedView ArticleGoogle Scholar
- Styczynski J, Reusser P, Einsele H, de la Camara R, Cordonnier C, Ward KN, Ljungman P, Engelhard D: Management of HSV, VZV and EBV infections in patients with hematological malignancies and after SCT: guidelines from the Second European Conference on Infections in Leukemia. Bone Marrow Transplant. 2009, 43 (10): 757-770. 10.1038/bmt.2008.386.PubMedView ArticleGoogle Scholar
- Hirsch HH, Martino R, Ward KN, Boeckh M, Einsele H, Ljungman P: Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus. Clin Infect Dis. 2013, 56 (2): 258-266. 10.1093/cid/cis844.PubMed CentralPubMedView ArticleGoogle Scholar
- Peck AJ, Englund JA, Kuypers J, Guthrie KA, Corey L, Morrow R, Hackman RC, Cent A, Boeckh M: Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection. Blood. 2007, 110 (5): 1681-1688. 10.1182/blood-2006-12-060343.PubMed CentralPubMedView ArticleGoogle Scholar
- Kadakia MP, Rybka WB, Stewart JA, Patton JL, Stamey FR, Elsawy M, Pellett PE, Armstrong JA: Human herpesvirus 6: infection and disease following autologous and allogeneic bone marrow transplantation. Blood. 1996, 87 (12): 5341-5354.PubMedGoogle Scholar
- Dewhurst S: Human herpesvirus type 6 and human herpesvirus type 7 infections of the central nervous system. Herpes. 2004, 11 (Suppl 2): 105A-111A.PubMedGoogle Scholar
- Yoshikawa T, Asano Y, Ihira M, Suzuki K, Ohashi M, Suga S, Kudo K, Horibe K, Kojima S, Kato K: Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors. J Infect Dis. 2002, 185 (7): 847-853. 10.1086/339411.PubMedView ArticleGoogle Scholar
- Jeulin H, Agrinier N, Guery M, Salmon A, Clement L, Bordigoni P, Venard V: Human herpesvirus 6 infection after allogeneic stem cell transplantation: incidence, outcome, and factors associated with HHV-6 reactivation. Transplantation. 2013, 95 (10): 1292-1298. 10.1097/TP.0b013e318289958b.PubMedView ArticleGoogle Scholar
- Ljungman P, Singh N: Human herpesvirus-6 infection in solid organ and stem cell transplant recipients. J Clin Virol. 2006, 37 (Suppl 1): S87-S91.PubMedView ArticleGoogle Scholar
- Storek J, Dawson MA, Storer B, Stevens-Ayers T, Maloney DG, Marr KA, Witherspoon RP, Bensinger W, Flowers ME, Martin P: Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation. Blood. 2001, 97 (11): 3380-3389. 10.1182/blood.V97.11.3380.PubMedView ArticleGoogle Scholar
- Styczynski J, Gil L, Tridello G, Ljungman P, Donnelly JP, van der Velden W, Omar H, Martino R, Halkes C, Faraci M: Response to rituximab-based therapy and risk factor analysis in epstein barr virus-related lymphoproliferative disorder after hematopoietic stem cell transplant in children and adults: a study from the infectious diseases working party of the European group for blood and marrow transplantation. Clin Infect Dis. 2013, 57 (6): 794-802. 10.1093/cid/cit391.PubMedView ArticleGoogle Scholar
- McGoldrick SM, Bleakley ME, Guerrero A, Turtle CJ, Yamamoto TN, Pereira SE, Delaney CS, Riddell SR: Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo. Blood. 2013, 121 (14): 2796-2803. 10.1182/blood-2012-09-453720.PubMed CentralPubMedView ArticleGoogle Scholar
- Chakrabarti S, Mackinnon S, Chopra R, Kottaridis PD, Peggs K, O'Gorman P, Chakraverty R, Marshall T, Osman H, Mahendra P: High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution. Blood. 2002, 99 (12): 4357-4363. 10.1182/blood.V99.12.4357.PubMedView ArticleGoogle Scholar
- Xuan L, Huang F, Fan Z, Zhou H, Zhang X, Yu G, Zhang Y, Liu C, Sun J, Liu Q: Effects of intensified conditioning on Epstein-Barr virus and cytomegalovirus infections in allogeneic hematopoietic stem cell transplantation for hematological malignancies. J Hematol Oncol. 2012, 5: 46-10.1186/1756-8722-5-46.PubMed CentralPubMedView ArticleGoogle Scholar
- Huan C, Kai-yan L, Lan-ping X, Dai-hong L, Yu-hong C, Xiang-yu Z, Wei H, Xiao-hui Z, Yu W, Yuan-yuan Z: Administration of imatinib after allogeneic hematopoietic stem cell transplantation may improve disease-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. J Hematol Oncol. 2012, 5: 29-10.1186/1756-8722-5-29.View ArticleGoogle Scholar
- Matthes-Martin S, Feuchtinger T, Shaw PJ, Engelhard D, Hirsch HH, Cordonnier C, Ljungman P: European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4 (2011). Transpl Infect Dis. 2012, 14 (6): 555-563. 10.1111/tid.12022.PubMedView ArticleGoogle Scholar
- Ison MG: Respiratory viral infections in transplant recipients. Antivir Ther. 2007, 12 (4 Pt B): 627-638.PubMedGoogle Scholar
- Leland DS, Ginocchio CC: Role of cell culture for virus detection in the age of technology. Clin Microbiol Rev. 2007, 20 (1): 49-78. 10.1128/CMR.00002-06.PubMed CentralPubMedView ArticleGoogle Scholar
- Talbot HK, Falsey AR: The diagnosis of viral respiratory disease in older adults. Clin Infect Dis. 2010, 50 (5): 747-751.PubMed CentralPubMedGoogle Scholar
- Hardie DR, Korsman SN, Hsiao NY: Cytomegalovirus load in whole blood is more reliable for predicting and assessing CMV disease than pp 65 antigenaemia. J Virol Methods. 2013, 193 (1): 166-168. 10.1016/j.jviromet.2013.06.019.PubMedView ArticleGoogle Scholar
- Yoshikawa T: Significance of human herpesviruses to transplant recipients. Curr Opin Infect Dis. 2003, 16 (6): 601-606. 10.1097/00001432-200312000-00014.PubMedView ArticleGoogle Scholar
- Yakushiji K, Gondo H, Kamezaki K, Shigematsu K, Hayashi S, Kuroiwa M, Taniguchi S, Ohno Y, Takase K, Numata A: Monitoring of cytomegalovirus reactivation after allogeneic stem cell transplantation: comparison of an antigenemia assay and quantitative real-time polymerase chain reaction. Bone Marrow Transplant. 2002, 29 (7): 599-606. 10.1038/sj.bmt.1703513.PubMedView ArticleGoogle Scholar
- Li H, Dummer JS, Estes WR, Meng S, Wright PF, Tang YW: Measurement of human cytomegalovirus loads by quantitative real-time PCR for monitoring clinical intervention in transplant recipients. J Clin Microbiol. 2003, 41 (1): 187-191. 10.1128/JCM.41.1.187-191.2003.PubMed CentralPubMedView ArticleGoogle Scholar
- Fan H, Robetorye RS: Epstein-Barr Virus (EBV) load determination using real-time quantitative polymerase chain reaction. Methods Mol Biol. 2013, 999: 231-243. 10.1007/978-1-62703-357-2_17.PubMedView ArticleGoogle Scholar
- Makol A, Kosuri K, Tamkus D, de Calaca MW, Chang HT: Lymphomatoid granulomatosis masquerading as interstitial pneumonia in a 66-year-old man: a case report and review of literature. J Hematol Oncol. 2009, 2: 39-10.1186/1756-8722-2-39.PubMed CentralPubMedView ArticleGoogle Scholar
- Rooney CM, Smith CA, Ng CY, Loftin SK, Sixbey JW, Gan Y, Srivastava DK, Bowman LC, Krance RA, Brenner MK: Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood. 1998, 92 (5): 1549-1555.PubMedGoogle Scholar
- Leen AM, Bollard CM, Mendizabal AM, Shpall EJ, Szabolcs P, Antin JH, Kapoor N, Pai SY, Rowley SD, Kebriaei P: Multicenter study of banked third party virus-specific T-cells to treat severe viral infections after hematopoietic stem cell transplantation. Blood. 2013, 121 (26): 5113-5123. 10.1182/blood-2013-02-486324.PubMed CentralPubMedView ArticleGoogle Scholar
- Einsele H, Roosnek E, Rufer N, Sinzger C, Riegler S, Loffler J, Grigoleit U, Moris A, Rammensee HG, Kanz L: Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood. 2002, 99 (11): 3916-3922. 10.1182/blood.V99.11.3916.PubMedView ArticleGoogle Scholar
- Brion A, Cahn JY, Mougin C, Angonin R, Flesch M, Deschaseaux ML, Plouvier E, Deconinck E, Voillat L, Racadot E: Herpes virus-related lymphoproliferative disorders following allogeneic bone marrow transplantation: clinical and biological characteristics of six cases. Nouv Rev Fr Hematol. 1995, 37 (6): 289-296.PubMedGoogle Scholar
- Erard V, Chien JW, Kim HW, Nichols WG, Flowers ME, Martin PJ, Corey L, Boeckh M: Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses. J Infect Dis. 2006, 193 (12): 1619-1625. 10.1086/504268.PubMedView ArticleGoogle Scholar
- Ghosh S, Champlin RE, Englund J, Giralt SA, Rolston K, Raad I, Jacobson K, Neumann J, Ippoliti C, Mallik S: Respiratory syncytial virus upper respiratory tract illnesses in adult blood and marrow transplant recipients: combination therapy with aerosolized ribavirin and intravenous immunoglobulin. Bone Marrow Transplant. 2000, 25 (7): 751-755. 10.1038/sj.bmt.1702228.PubMedView ArticleGoogle Scholar
- Lewinsohn DM, Bowden RA, Mattson D, Crawford SW: Phase I study of intravenous ribavirin treatment of respiratory syncytial virus pneumonia after marrow transplantation. Antimicrob Agents Chemother. 1996, 40 (11): 2555-2557.PubMed CentralPubMedGoogle Scholar
- Saral R, Burns WH, Laskin OL, Santos GW, Lietman PS: Acyclovir prophylaxis of herpes-simplex-virus infections. N Engl J Med. 1981, 305 (2): 63-67. 10.1056/NEJM198107093050202.PubMedView ArticleGoogle Scholar
- Ljungman P, Cordonnier C, Einsele H, Englund J, Machado CM, Storek J, Small T: Vaccination of hematopoietic cell transplant recipients. Bone Marrow Transplant. 2009, 44 (8): 521-526. 10.1038/bmt.2009.263.PubMedView ArticleGoogle Scholar
- Cheuk DK, Chiang AK, Lee TL, Chan GC, Ha SY: Vaccines for prophylaxis of viral infections in patients with hematological malignancies. Cochrane Database Syst Rev. 2011, 3: D6505-Google Scholar
- Engelhard D, Mohty B, de la Camara R, Cordonnier C, Ljungman P: European guidelines for prevention and management of influenza in hematopoietic stem cell transplantation and leukemia patients: summary of ECIL-4 (2011), on behalf of ECIL, a joint venture of EBMT, EORTC, ICHS and ELN. Transpl Infect Dis. 2013, 15 (3): 219-232. 10.1111/tid.12054.PubMedView ArticleGoogle Scholar
- Ruuskanen O, Lahti E, Jennings LC, Murdoch DR: Viral pneumonia. Lancet. 2011, 377 (9773): 1264-1275. 10.1016/S0140-6736(10)61459-6.PubMedView ArticleGoogle Scholar
- Barton TD, Blumberg EA: Viral pneumonias other than cytomegalovirus in transplant recipients. Clin Chest Med. 2005, 26 (4): 707-720. 10.1016/j.ccm.2005.06.004.PubMedView ArticleGoogle Scholar
- Ison MG, Hayden FG: Viral infections in immunocompromised patients: what's new with respiratory viruses?. Curr Opin Infect Dis. 2002, 15 (4): 355-367. 10.1097/00001432-200208000-00002.PubMedView ArticleGoogle Scholar
- Symeonidis N, Jakubowski A, Pierre-Louis S, Jaffe D, Pamer E, Sepkowitz K, O'Reilly RJ, Papanicolaou GA: Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir. Transpl Infect Dis. 2007, 9 (2): 108-113. 10.1111/j.1399-3062.2006.00184.x.PubMedView ArticleGoogle Scholar
- Ljungman P, Ward KN, Crooks BN, Parker A, Martino R, Shaw PJ, Brinch L, Brune M, De La Camara R, Dekker A: Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant. 2001, 28 (5): 479-484. 10.1038/sj.bmt.1703139.PubMedView ArticleGoogle Scholar
- Travi G, Pergam SA: Cytomegalovirus pneumonia in hematopoietic stem cell recipients. J Intensive Care Med. 2013, PMID: 23753231-Google Scholar
- Granena A, Carreras E, Rozman C, Salgado C, Sierra J, Algara M, Rovira M, Valls A: Interstitial pneumonitis after BMT: 15 years experience in a single institution. Bone Marrow Transplant. 1993, 11 (6): 453-458.PubMedGoogle Scholar
- Boeckh M, Leisenring W, Riddell SR, Bowden RA, Huang ML, Myerson D, Stevens-Ayers T, Flowers ME, Cunningham T, Corey L: Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity. Blood. 2003, 101 (2): 407-414. 10.1182/blood-2002-03-0993.PubMedView ArticleGoogle Scholar
- van Esser JW, van der Holt B, Meijer E, Niesters HG, Trenschel R, Thijsen SF, van Loon AM, Frassoni F, Bacigalupo A, Schaefer UW: Epstein-Barr virus (EBV) reactivation is a frequent event after allogeneic stem cell transplantation (SCT) and quantitatively predicts EBV-lymphoproliferative disease following T-cell–depleted SCT. Blood. 2001, 98 (4): 972-978. 10.1182/blood.V98.4.972.PubMedView ArticleGoogle Scholar
- Schmidt-Hieber M, Schwender J, Heinz WJ, Zabelina T, Kuhl JS, Mousset S, Schuttrumpf S, Junghanss C, Silling G, Basara N: Viral encephalitis after allogeneic stem cell transplantation: a rare complication with distinct characteristics of different causative agents. Haematologica. 2011, 96 (1): 142-149. 10.3324/haematol.2010.029876.PubMed CentralPubMedView ArticleGoogle Scholar
- Wu M, Huang F, Jiang X, Fan Z, Zhou H, Liu C, Jiang Q, Zhang Y, Zhao K, Xuan L: Herpesvirus-associated central nervous system diseases after allogeneic hematopoietic stem cell transplantation. PLoS One. 2013, 8 (10): e77805-10.1371/journal.pone.0077805.PubMed CentralPubMedView ArticleGoogle Scholar
- Schmidt-Hieber M, Zweigner J, Uharek L, Blau IW, Thiel E: Central nervous system infections in immunocompromised patients: update on diagnostics and therapy. Leuk Lymphoma. 2009, 50 (1): 24-36. 10.1080/10428190802517740.PubMedView ArticleGoogle Scholar
- Walter JE, Mitchell DK: Astrovirus infection in children. Curr Opin Infect Dis. 2003, 16 (3): 247-253. 10.1097/00001432-200306000-00011.PubMedView ArticleGoogle Scholar
- van Kraaij MG, Dekker AW, Verdonck LF, van Loon AM, Vinje J, Koopmans MP, Rozenberg-Arska M: Infectious gastro-enteritis: an uncommon cause of diarrhoea in adult allogeneic and autologous stem cell transplant recipients. Bone Marrow Transplant. 2000, 26 (3): 299-303. 10.1038/sj.bmt.1702484.PubMedView ArticleGoogle Scholar
- Anderson EJ, Weber SG: Rotavirus infection in adults. Lancet Infect Dis. 2004, 4 (2): 91-99. 10.1016/S1473-3099(04)00928-4.PubMedView ArticleGoogle Scholar
- Yusuf U, Hale GA, Carr J, Gu Z, Benaim E, Woodard P, Kasow KA, Horwitz EM, Leung W, Srivastava DK: Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients. Transplantation. 2006, 81 (10): 1398-1404. 10.1097/01.tp.0000209195.95115.8e.PubMedView ArticleGoogle Scholar
- Ljungman P, Ribaud P, Eyrich M, Matthes-Martin S, Einsele H, Bleakley M, Machaczka M, Bierings M, Bosi A, Gratecos N: Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant. 2003, 31 (6): 481-486. 10.1038/sj.bmt.1703798.PubMedView ArticleGoogle Scholar
- Robles JD, Cheuk DK, Ha SY, Chiang AK, Chan GC: Norovirus infection in pediatric hematopoietic stem cell transplantation recipients: incidence, risk factors, and outcome. Biol Blood Marrow Transplant. 2012, 18 (12): 1883-1889. 10.1016/j.bbmt.2012.07.005.PubMedView ArticleGoogle Scholar
- van Burik JA, Lawatsch EJ, DeFor TE, Weisdorf DJ: Cytomegalovirus enteritis among hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant. 2001, 7 (12): 674-679. 10.1053/bbmt.2001.v7.pm11787530.PubMedView ArticleGoogle Scholar
- Locasciulli A, Testa M, Valsecchi MG, Bacigalupo A, Solinas S, Tomas JF, Ljungman P, Alberti A: The role of hepatitis C and B virus infections as risk factors for severe liver complications following allogeneic BMT: a prospective study by the Infectious Disease Working Party of the European Blood and Marrow Transplantation Group. Transplantation. 1999, 68 (10): 1486-1491. 10.1097/00007890-199911270-00010.PubMedView ArticleGoogle Scholar
- Lalazar G, Rund D, Shouval D: Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies. Br J Haematol. 2007, 136 (5): 699-712. 10.1111/j.1365-2141.2006.06465.x.PubMedView ArticleGoogle Scholar
- Locasciulli A, Bruno B, Alessandrino EP, Meloni G, Arcese W, Bandini G, Cassibba V, Rotoli B, Morra E, Majolino I: Hepatitis reactivation and liver failure in haemopoietic stem cell transplants for hepatitis B virus (HBV)/hepatitis C virus (HCV) positive recipients: a retrospective study by the Italian group for blood and marrow transplantation. Bone Marrow Transplant. 2003, 31 (4): 295-300. 10.1038/sj.bmt.1703826.PubMedView ArticleGoogle Scholar
- Cui Y, Jia J: Update on epidemiology of hepatitis B and C in China. J Gastroenterol Hepatol. 2013, 28 (Suppl 1): 7-10.PubMedView ArticleGoogle Scholar
- Strasser SI, Myerson D, Spurgeon CL, Sullivan KM, Storer B, Schoch HG, Kim S, Flowers ME, McDonald GB: Hepatitis C virus infection and bone marrow transplantation: a cohort study with 10-year follow-up. Hepatology. 1999, 29 (6): 1893-1899. 10.1002/hep.510290609.PubMedView ArticleGoogle Scholar
- Tsuboi K, Kishi K, Ohmachi K, Yasuda Y, Shimizu T, Inoue H, Matsumoto M, Hattori K, Yoshiba F, Watanabe S: Multivariate analysis of risk factors for hemorrhagic cystitis after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2003, 32 (9): 903-907. 10.1038/sj.bmt.1704240.PubMedView ArticleGoogle Scholar
- Kloos RQ, Boelens JJ, de Jong TP, Versluys B, Bierings M: Hemorrhagic cystitis in a cohort of pediatric transplantations: incidence, treatment, outcome, and risk factors. Biol Blood Marrow Transplant. 2013, 19 (8): 1263-1266. 10.1016/j.bbmt.2013.05.014.PubMedView ArticleGoogle Scholar
- Bedi A, Miller CB, Hanson JL, Goodman S, Ambinder RF, Charache P, Arthur RR, Jones RJ: Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol. 1995, 13 (5): 1103-1109.PubMedGoogle Scholar
- Leung AY, Mak R, Lie AK, Yuen KY, Cheng VC, Liang R, Kwong YL: Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation. Bone Marrow Transplant. 2002, 29 (6): 509-513. 10.1038/sj.bmt.1703415.PubMedView ArticleGoogle Scholar
- Han TT, Xu LP, Liu DH, Liu KY, Fu HX, Zhao XY, Zhao XS, Huang XJ: Cytomegalovirus is a potential risk factor for late-onset hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2013, doi: 10.1002/ajh.23584Google Scholar
- Akiyama H, Kurosu T, Sakashita C, Inoue T, Mori S, Ohashi K, Tanikawa S, Sakamaki H, Onozawa Y, Chen Q: Adenovirus is a key pathogen in hemorrhagic cystitis associated with bone marrow transplantation. Clin Infect Dis. 2001, 32 (9): 1325-1330. 10.1086/319992.PubMedView ArticleGoogle Scholar
- Tsao SY, Chang KC, Chen YP, Yeh YM, Su WC, Chen TY: Cytomegalovirus and Epstein-Barr virus-associated post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation. Ann Hematol. 2011, 90 (1): 113-114. 10.1007/s00277-010-0947-8.PubMedView ArticleGoogle Scholar
- Manez R, Breinig MC, Linden P, Wilson J, Torre-Cisneros J, Kusne S, Dummer S, Ho M: Posttransplant lymphoproliferative disease in primary Epstein-Barr virus infection after liver transplantation: the role of cytomegalovirus disease. J Infect Dis. 1997, 176 (6): 1462-1467. 10.1086/514142.PubMedView ArticleGoogle Scholar
- Comoli P, Basso S, Zecca M, Pagliara D, Baldanti F, Bernardo ME, Barberi W, Moretta A, Labirio M, Paulli M: Preemptive therapy of EBV-related lymphoproliferative disease after pediatric haploidentical stem cell transplantation. Am J Transplant. 2007, 7 (6): 1648-1655. 10.1111/j.1600-6143.2007.01823.x.PubMedView ArticleGoogle Scholar
- Zutter MM, Martin PJ, Sale GE, Shulman HM, Fisher L, Thomas ED, Durnam DM: Epstein-Barr virus lymphoproliferation after bone marrow transplantation. Blood. 1988, 72 (2): 520-529.PubMedGoogle Scholar
- Sundin M, Le Blanc K, Ringden O, Barkholt L, Omazic B, Lergin C, Levitsky V, Remberger M: The role of HLA mismatch, splenectomy and recipient Epstein-Barr virus seronegativity as risk factors in post-transplant lymphoproliferative disorder following allogeneic hematopoietic stem cell transplantation. Haematologica. 2006, 91 (8): 1059-1067.PubMedGoogle Scholar
- Curtis RE, Travis LB, Rowlings PA, Socie G, Kingma DW, Banks PM, Jaffe ES, Sale GE, Horowitz MM, Witherspoon RP: Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study. Blood. 1999, 94 (7): 2208-2216.PubMedGoogle Scholar
- Meijer E, Cornelissen JJ: Epstein-Barr virus-associated lymphoproliferative disease after allogeneic haematopoietic stem cell transplantation: molecular monitoring and early treatment of high-risk patients. Curr Opin Hematol. 2008, 15 (6): 576-585. 10.1097/MOH.0b013e328311f438.PubMedView ArticleGoogle Scholar
- Chiang KY, Hazlett LJ, Godder KT, Abhyankar SH, Christiansen NP, van Rhee F, Lee CG, Bridges K, Parrish RS, Henslee-Downey PJ: Epstein-Barr virus-associated B cell lymphoproliferative disorder following mismatched related T cell-depleted bone marrow transplantation. Bone Marrow Transplant. 2001, 28 (12): 1117-1123. 10.1038/sj.bmt.1703311.PubMedView ArticleGoogle Scholar
- Nozzoli C, Bartolozzi B, Guidi S, Orsi A, Vannucchi AM, Leoni F, Bosi A: Epstein-Barr virus-associated post-transplant lymphoproliferative disease with central nervous system involvement after unrelated allogeneic hematopoietic stem cell transplantation. Leuk Lymphoma. 2006, 47 (1): 167-169. 10.1080/10428190500254208.PubMedView ArticleGoogle Scholar
- Shimizu H, Saitoh T, Koya H, Yuzuriha A, Hoshino T, Hatsumi N, Takada S, Nagaki T, Nojima Y, Sakura T: Discrepancy in EBV-DNA load between peripheral blood and cerebrospinal fluid in a patient with isolated CNS post-transplant lymphoproliferative disorder. Int J Hematol. 2011, 94 (5): 495-498. 10.1007/s12185-011-0951-3.PubMedView ArticleGoogle Scholar
- Kittan NA, Beier F, Kurz K, Niller HH, Egger L, Jilg W, Andreesen R, Holler E, Hildebrandt GC: Isolated cerebral manifestation of Epstein-Barr virus-associated post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: a case of clinical and diagnostic challenges. Transpl Infect Dis. 2011, 13 (5): 524-530. 10.1111/j.1399-3062.2011.00621.x.PubMedView ArticleGoogle Scholar
- DiNardo CD, Tsai DE: Treatment advances in posttransplant lymphoproliferative disease. Curr Opin Hematol. 2010, 17 (4): 368-374. 10.1097/MOH.0b013e328339018c.PubMedView ArticleGoogle Scholar
- Ljungman P, Griffiths P, Paya C: Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis. 2002, 34 (8): 1094-1097. 10.1086/339329.PubMedView ArticleGoogle Scholar
- Ljungman P, Hakki M, Boeckh M: Cytomegalovirus in hematopoietic stem cell transplant recipients. Infect Dis Clin North Am. 2010, 24 (2): 319-337. 10.1016/j.idc.2010.01.008.PubMedView ArticleGoogle Scholar
- Meyers JD, Flournoy N, Thomas ED: Infection with herpes simplex virus and cell-mediated immunity after marrow transplant. J Infect Dis. 1980, 142 (3): 338-346. 10.1093/infdis/142.3.338.PubMedView ArticleGoogle Scholar
- Kawamura K, Wada H, Yamasaki R, Ishihara Y, Sakamoto K, Ashizawa M, Sato M, Machishima T, Terasako K, Kimura SI: Low-dose acyclovir prophylaxis for the prevention of herpes simplex virus disease after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 2013, 15 (5): 457-465.PubMedGoogle Scholar
- Dykewicz CA, Kaplan JE: Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR Recomm Rep. 2000, 49 (RR-10): 1-125. E1-E7Google Scholar
- Liesveld JL, Abboud CN, Ifthikharuddin JJ, Lancet JE, Wedow LA, Oliva J, Stamm CG, Nichols D: Oral valacyclovir versus intravenous acyclovir in preventing herpes simplex virus infections in autologous stem cell transplant recipients. Biol Blood Marrow Transplant. 2002, 8 (12): 662-665. 10.1053/bbmt.2002.v8.abbmt080662.PubMedView ArticleGoogle Scholar
- Orlowski RZ, Mills SR, Hartley EE, Ye X, Piantadosi S, Ambinder RF, Gore SD, Miller CB: Oral valacyclovir as prophylaxis against herpes simplex virus reactivation during high dose chemotherapy for leukemia. Leuk Lymphoma. 2004, 45 (11): 2215-2219. 10.1080/10428190410001733763.PubMedView ArticleGoogle Scholar
- Hoglund M, Ljungman P, Weller S: Comparable aciclovir exposures produced by oral valaciclovir and intravenous aciclovir in immunocompromised cancer patients. J Antimicrob Chemother. 2001, 47 (6): 855-861. 10.1093/jac/47.6.855.PubMedView ArticleGoogle Scholar
- Blot N, Schneider P, Young P, Janvresse C, Dehesdin D, Tron P, Vannier JP: Treatment of an acyclovir and foscarnet-resistant herpes simplex virus infection with cidofovir in a child after an unrelated bone marrow transplant. Bone Marrow Transplant. 2000, 26 (8): 903-905. 10.1038/sj.bmt.1702591.PubMedView ArticleGoogle Scholar
- Zaia JA, Levin MJ, Preblud SR, Leszczynski J, Wright GG, Ellis RJ, Curtis AC, Valerio MA, LeGore J: Evaluation of varicella-zoster immune globulin: protection of immunosuppressed children after household exposure to varicella. J Infect Dis. 1983, 147 (4): 737-743. 10.1093/infdis/147.4.737.PubMedView ArticleGoogle Scholar
- Feldman S, Lott L: Varicella in children with cancer: impact of antiviral therapy and prophylaxis. Pediatrics. 1987, 80 (4): 465-472.PubMedGoogle Scholar
- Weinstock DM, Boeckh M, Sepkowitz KA: Postexposure prophylaxis against varicella zoster virus infection among hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant. 2006, 12 (10): 1096-1097. 10.1016/j.bbmt.2006.06.005.PubMedView ArticleGoogle Scholar
- Ljungman P, Wilczek H, Gahrton G, Gustavsson A, Lundgren G, Lonnqvist B, Ringden O, Wahren B: Long-term acyclovir prophylaxis in bone marrow transplant recipients and lymphocyte proliferation responses to herpes virus antigens in vitro. Bone Marrow Transplant. 1986, 1 (2): 185-192.PubMedGoogle Scholar
- Perren TJ, Powles RL, Easton D, Stolle K, Selby PJ: Prevention of herpes zoster in patients by long-term oral acyclovir after allogeneic bone marrow transplantation. Am J Med. 1988, 85 (2A): 99-101.PubMedGoogle Scholar
- Boeckh M, Kim HW, Flowers ME, Meyers JD, Bowden RA: Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation–a randomized double-blind placebo-controlled study. Blood. 2006, 107 (5): 1800-1805. 10.1182/blood-2005-09-3624.PubMed CentralPubMedView ArticleGoogle Scholar
- Oshima K, Takahashi T, Mori T, Matsuyama T, Usuki K, Asano-Mori Y, Nakahara F, Okamoto S, Kurokawa M, Kanda Y: One-year low-dose valacyclovir as prophylaxis for varicella zoster virus disease after allogeneic hematopoietic stem cell transplantation. A prospective study of the Japan Hematology and Oncology Clinical Study Group. Transpl Infect Dis. 2010, 12 (5): 421-427. 10.1111/j.1399-3062.2010.00541.x.PubMedView ArticleGoogle Scholar
- Serota FT, Starr SE, Bryan CK, Koch PA, Plotkin SA, August CS: Acyclovir treatment of herpes zoster infections. Use in children undergoing bone marrow transplantation. JAMA. 1982, 247 (15): 2132-2135. 10.1001/jama.1982.03320400044032.PubMedView ArticleGoogle Scholar
- Shepp DH, Dandliker PS, Meyers JD: Treatment of varicella-zoster virus infection in severely immunocompromised patients. A randomized comparison of acyclovir and vidarabine. N Engl J Med. 1986, 314 (4): 208-212. 10.1056/NEJM198601233140404.PubMedView ArticleGoogle Scholar
- Tyring S, Belanger R, Bezwoda W, Ljungman P, Boon R, Saltzman RL: A randomized, double-blind trial of famciclovir versus acyclovir for the treatment of localized dermatomal herpes zoster in immunocompromised patients. Cancer Invest. 2001, 19 (1): 13-22. 10.1081/CNV-100000070.PubMedView ArticleGoogle Scholar
- Wassilew SW, Wutzler P: Oral brivudin in comparison with acyclovir for improved therapy of herpes zoster in immunocompetent patients: results of a randomized, double-blind, multicentered study. Antiviral Res. 2003, 59 (1): 49-56. 10.1016/S0166-3542(03)00065-2.PubMedView ArticleGoogle Scholar
- Reusser P, Cordonnier C, Einsele H, Engelhard D, Link D, Locasciulli A, Ljungman P: European survey of herpesvirus resistance to antiviral drugs in bone marrow transplant recipients. Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant. 1996, 17 (5): 813-817.PubMedGoogle Scholar
- Yanada M, Yamamoto K, Emi N, Naoe T, Suzuki R, Taji H, Iida H, Shimokawa T, Kohno A, Mizuta S: Cytomegalovirus antigenemia and outcome of patients treated with pre-emptive ganciclovir: retrospective analysis of 241 consecutive patients undergoing allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2003, 32 (8): 801-807. 10.1038/sj.bmt.1704232.PubMedView ArticleGoogle Scholar
- Ljungman P, Engelhard D, Link H, Biron P, Brandt L, Brunet S, Cordonnier C, Debusscher L, de Laurenzi A, Kolb HJ: Treatment of interstitial pneumonitis due to cytomegalovirus with ganciclovir and intravenous immune globulin: experience of European Bone Marrow Transplant Group. Clin Infect Dis. 1992, 14 (4): 831-835. 10.1093/clinids/14.4.831.PubMedView ArticleGoogle Scholar
- Nichols WG, Corey L, Gooley T, Drew WL, Miner R, Huang M, Davis C, Boeckh M: Rising pp 65 antigenemia during preemptive anticytomegalovirus therapy after allogeneic hematopoietic stem cell transplantation: risk factors, correlation with DNA load, and outcomes. Blood. 2001, 97 (4): 867-874. 10.1182/blood.V97.4.867.PubMedView ArticleGoogle Scholar
- Einsele H, Ehninger G, Hebart H, Wittkowski KM, Schuler U, Jahn G, Mackes P, Herter M, Klingebiel T, Loffler J: Polymerase chain reaction monitoring reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation. Blood. 1995, 86 (7): 2815-2820.PubMedGoogle Scholar
- Winston DJ, Ho WG, Bartoni K, Du Mond C, Ebeling DF, Buhles WC, Champlin RE: Ganciclovir prophylaxis of cytomegalovirus infection and disease in allogeneic bone marrow transplant recipients. Results of a placebo-controlled, double-blind trial. Ann Intern Med. 1993, 118 (3): 179-184. 10.7326/0003-4819-118-3-199302010-00004.PubMedView ArticleGoogle Scholar
- Goodrich JM, Bowden RA, Fisher L, Keller C, Schoch G, Meyers JD: Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant. Ann Intern Med. 1993, 118 (3): 173-178. 10.7326/0003-4819-118-3-199302010-00003.PubMedView ArticleGoogle Scholar
- Einsele H, Reusser P, Bornhauser M, Kalhs P, Ehninger G, Hebart H, Chalandon Y, Kroger N, Hertenstein B, Rohde F: Oral valganciclovir leads to higher exposure to ganciclovir than intravenous ganciclovir in patients following allogeneic stem cell transplantation. Blood. 2006, 107 (7): 3002-3008. 10.1182/blood-2005-09-3786.PubMedView ArticleGoogle Scholar
- Cooper N, Rao K, Goulden N, Webb D, Amrolia P, Veys P: The use of reduced-intensity stem cell transplantation in haemophagocytic lymphohistiocytosis and Langerhans cell histiocytosis. Bone Marrow Transplant. 2008, 42 (Suppl 2): S47-S50.PubMedView ArticleGoogle Scholar
- van der Heiden PL, Kalpoe JS, Barge RM, Willemze R, Kroes AC, Schippers EF: Oral valganciclovir as pre-emptive therapy has similar efficacy on cytomegalovirus DNA load reduction as intravenous ganciclovir in allogeneic stem cell transplantation recipients. Bone Marrow Transplant. 2006, 37 (7): 693-698. 10.1038/sj.bmt.1705311.PubMedView ArticleGoogle Scholar
- Reed EC, Bowden RA, Dandliker PS, Lilleby KE, Meyers JD: Treatment of cytomegalovirus pneumonia with ganciclovir and intravenous cytomegalovirus immunoglobulin in patients with bone marrow transplants. Ann Intern Med. 1988, 109 (10): 783-788. 10.7326/0003-4819-109-10-783.PubMedView ArticleGoogle Scholar
- Ljungman P, Deliliers GL, Platzbecker U, Matthes-Martin S, Bacigalupo A, Einsele H, Ullmann J, Musso M, Trenschel R, Ribaud P: Cidofovir for cytomegalovirus infection and disease in allogeneic stem cell transplant recipients. The Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Blood. 2001, 97 (2): 388-392. 10.1182/blood.V97.2.388.PubMedView ArticleGoogle Scholar
- Blyth E, Clancy L, Simms R, Ma CK, Burgess J, Deo S, Byth K, Dubosq MC, Shaw PJ, Micklethwaite KP: Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation. Blood. 2013, 121 (18): 3745-3758. 10.1182/blood-2012-08-448977.PubMedView ArticleGoogle Scholar
- Liu Q, Xuan L, Liu H, Huang F, Zhou H, Fan Z, Zhao K, Wu M, Xu L, Zhai X: Molecular monitoring and stepwise preemptive therapy for Epstein-Barr virus viremia after allogeneic stem cell transplantation. Am J Hematol. 2013, 88 (7): 550-555. 10.1002/ajh.23452.PubMedView ArticleGoogle Scholar
- Stevens SJ, Verschuuren EA, Pronk I, van Der Bij W, Harmsen MC, The TH, Meijer CJ, van Den Brule AJ, Middeldorp JM: Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patients. Blood. 2001, 97 (5): 1165-1171. 10.1182/blood.V97.5.1165.PubMedView ArticleGoogle Scholar
- Heslop HE, Slobod KS, Pule MA, Hale GA, Rousseau A, Smith CA, Bollard CM, Liu H, Wu MF, Rochester RJ: Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. Blood. 2010, 115 (5): 925-935. 10.1182/blood-2009-08-239186.PubMed CentralPubMedView ArticleGoogle Scholar
- Peric Z, Cahu X, Chevallier P, Brissot E, Malard F, Guillaume T, Delaunay J, Ayari S, Dubruille V, Le Gouill S: Features of Epstein-Barr Virus (EBV) reactivation after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation. Leukemia. 2011, 25 (6): 932-938. 10.1038/leu.2011.26.PubMedView ArticleGoogle Scholar
- Perrine SP, Hermine O, Small T, Suarez F, O'Reilly R, Boulad F, Fingeroth J, Askin M, Levy A, Mentzer SJ: A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies. Blood. 2007, 109 (6): 2571-2578. 10.1182/blood-2006-01-024703.PubMed CentralPubMedView ArticleGoogle Scholar
- Faller DV, Mentzer SJ, Perrine SP: Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignancies. Curr Opin Oncol. 2001, 13 (5): 360-367. 10.1097/00001622-200109000-00008.PubMedView ArticleGoogle Scholar
- Elstrom RL, Andreadis C, Aqui NA, Ahya VN, Bloom RD, Brozena SC, Olthoff KM, Schuster SJ, Nasta SD, Stadtmauer EA: Treatment of PTLD with rituximab or chemotherapy. Am J Transplant. 2006, 6 (3): 569-576. 10.1111/j.1600-6143.2005.01211.x.PubMedView ArticleGoogle Scholar
- Choquet S, Leblond V, Herbrecht R, Socie G, Stoppa AM, Vandenberghe P, Fischer A, Morschhauser F, Salles G, Feremans W: Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: results of a prospective multicenter phase 2 study. Blood. 2006, 107 (8): 3053-3057. 10.1182/blood-2005-01-0377.PubMedView ArticleGoogle Scholar
- Milpied N, Vasseur B, Parquet N, Garnier JL, Antoine C, Quartier P, Carret AS, Bouscary D, Faye A, Bourbigot B: Humanized anti-CD20 monoclonal antibody (Rituximab) in post transplant B-lymphoproliferative disorder: a retrospective analysis on 32 patients. Ann Oncol. 2000, 11 (Suppl 1): 113-116. 10.1093/annonc/11.suppl_1.S113.PubMedView ArticleGoogle Scholar
- Faye A, Quartier P, Reguerre Y, Lutz P, Carret AS, Dehee A, Rohrlich P, Peuchmaur M, Matthieu-Boue A, Fischer A: Chimaeric anti-CD20 monoclonal antibody (rituximab) in post-transplant B-lymphoproliferative disorder following stem cell transplantation in children. Br J Haematol. 2001, 115 (1): 112-118. 10.1046/j.1365-2141.2001.03041.x.PubMedView ArticleGoogle Scholar
- Styczynski J, Einsele H, Gil L, Ljungman P: Outcome of treatment of Epstein-Barr virus-related post-transplant lymphoproliferative disorder in hematopoietic stem cell recipients: a comprehensive review of reported cases. Transpl Infect Dis. 2009, 11 (5): 383-392. 10.1111/j.1399-3062.2009.00411.x.PubMedView ArticleGoogle Scholar
- Wagner HJ, Cheng YC, Huls MH, Gee AP, Kuehnle I, Krance RA, Brenner MK, Rooney CM, Heslop HE: Prompt versus preemptive intervention for EBV lymphoproliferative disease. Blood. 2004, 103 (10): 3979-3981. 10.1182/blood-2003-12-4287.PubMedView ArticleGoogle Scholar
- Gross TG, Bucuvalas JC, Park JR, Greiner TC, Hinrich SH, Kaufman SS, Langnas AN, McDonald RA, Ryckman FC, Shaw BW: Low-dose chemotherapy for Epstein-Barr virus-positive post-transplantation lymphoproliferative disease in children after solid organ transplantation. J Clin Oncol. 2005, 23 (27): 6481-6488. 10.1200/JCO.2005.08.074.PubMedView ArticleGoogle Scholar
- Trappe R, Oertel S, Leblond V, Mollee P, Sender M, Reinke P, Neuhaus R, Lehmkuhl H, Horst HA, Salles G: Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial. Lancet Oncol. 2012, 13 (2): 196-206. 10.1016/S1470-2045(11)70300-X.PubMedView ArticleGoogle Scholar
- Gong JZ, Bayerl MG, Sandhaus LM, Sebastian S, Rehder CW, Routbort M, Lagoo AS, Szabolcs P, Chiu J, Comito M: Posttransplant lymphoproliferative disorder after umbilical cord blood transplantation in children. Am J Surg Pathol. 2006, 30 (3): 328-336.PubMedGoogle Scholar
- Maximiano AC, Sanchez RA, Cantos SDIB, Mendez GM, Ronco IS, Provencio PM: Ocular relapse of primary brain lymphoma in immunocompetent patient, treated with intrathecal rituximab. Clin Transl Oncol. 2010, 12 (10): 701-703. 10.1007/s12094-010-0580-y.View ArticleGoogle Scholar
- Bonney DK, Htwe EE, Turner A, Kelsey A, Shabani A, Hughes S, Hughes I, Wynn RF: Sustained response to intrathecal rituximab in EBV associated Post-transplant lymphoproliferative disease confined to the central nervous system following haematopoietic stem cell transplant. Pediatr Blood Cancer. 2012, 58 (3): 459-461. 10.1002/pbc.23134.PubMedView ArticleGoogle Scholar
- Czyzewski K, Styczynski J, Krenska A, Debski R, Zajac-Spychala O, Wachowiak J, Wysocki M: Intrathecal therapy with rituximab in central nervous system involvement of post-transplant lymphoproliferative disorder. Leuk Lymphoma. 2013, 54 (3): 503-506. 10.3109/10428194.2012.718342.PubMedView ArticleGoogle Scholar
- Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M: Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma. J Clin Oncol. 2007, 25 (11): 1350-1356. 10.1200/JCO.2006.09.7311.PubMedView ArticleGoogle Scholar
- Kinch A, Oberg G, Arvidson J, Falk KI, Linde A, Pauksens K: Post-transplant lymphoproliferative disease and other Epstein-Barr virus diseases in allogeneic haematopoietic stem cell transplantation after introduction of monitoring of viral load by polymerase chain reaction. Scand J Infect Dis. 2007, 39 (3): 235-244. 10.1080/00365540600978906.PubMedView ArticleGoogle Scholar
- Tokimasa S, Hara J, Osugi Y, Ohta H, Matsuda Y, Fujisaki H, Sawada A, Kim JY, Sashihara J, Amou K: Ganciclovir is effective for prophylaxis and treatment of human herpesvirus-6 in allogeneic stem cell transplantation. Bone Marrow Transplant. 2002, 29 (7): 595-598. 10.1038/sj.bmt.1703423.PubMedView ArticleGoogle Scholar
- Rapaport D, Engelhard D, Tagger G, Or R, Frenkel N: Antiviral prophylaxis may prevent human herpesvirus-6 reactivation in bone marrow transplant recipients. Transpl Infect Dis. 2002, 4 (1): 10-16. 10.1034/j.1399-3062.2002.040101.x.PubMedView ArticleGoogle Scholar
- Zerr DM, Gupta D, Huang ML, Carter R, Corey L: Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. Clin Infect Dis. 2002, 34 (3): 309-317. 10.1086/338044.PubMedView ArticleGoogle Scholar
- Gantt S, Casper C: Human herpesvirus 8-associated neoplasms: the roles of viral replication and antiviral treatment. Curr Opin Infect Dis. 2011, 24 (4): 295-301. 10.1097/QCO.0b013e3283486d04.PubMed CentralPubMedView ArticleGoogle Scholar
- Luppi M, Barozzi P, Schulz TF, Setti G, Staskus K, Trovato R, Narni F, Donelli A, Maiorana A, Marasca R: Bone marrow failure associated with human herpesvirus 8 infection after transplantation. N Engl J Med. 2000, 343 (19): 1378-1385. 10.1056/NEJM200011093431905.PubMedView ArticleGoogle Scholar
- Luppi M, Barozzi P, Schulz TF, Trovato R, Donelli A, Narni F, Sheldon J, Marasca R, Torelli G: Nonmalignant disease associated with human herpesvirus 8 reactivation in patients who have undergone autologous peripheral blood stem cell transplantation. Blood. 2000, 96 (7): 2355-2357.PubMedGoogle Scholar
- Erer B, Angelucci E, Muretto P, Ripalti M, Rapa S, Gaziev D, Baronciani D: Kaposi's sarcoma after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1997, 19 (6): 629-631. 10.1038/sj.bmt.1700703.PubMedView ArticleGoogle Scholar
- Cuzzola M, Irrera G, Iacopino O, Cuzzocrea A, Messina G, Console G, Iacopino P, Morabito F: Bone marrow failure associated with herpesvirus 8 infection in a patient undergoing autologous peripheral blood stem cell transplantation. Clin Infect Dis. 2003, 37 (7): e102-e106. 10.1086/377268.PubMedView ArticleGoogle Scholar
- Small TN, Casson A, Malak SF, Boulad F, Kiehn TE, Stiles J, Ushay HM, Sepkowitz KA: Respiratory syncytial virus infection following hematopoietic stem cell transplantation. Bone Marrow Transplant. 2002, 29 (4): 321-327. 10.1038/sj.bmt.1703365.PubMedView ArticleGoogle Scholar
- Shah JN, Chemaly RF: Management of RSV infections in adult recipients of hematopoietic stem cell transplantation. Blood. 2011, 117 (10): 2755-2763. 10.1182/blood-2010-08-263400.PubMedView ArticleGoogle Scholar
- Nichols WG, Corey L, Gooley T, Davis C, Boeckh M: Parainfluenza virus infections after hematopoietic stem cell transplantation: risk factors, response to antiviral therapy, and effect on transplant outcome. Blood. 2001, 98 (3): 573-578. 10.1182/blood.V98.3.573.PubMedView ArticleGoogle Scholar
- Elizaga J, Olavarria E, Apperley J, Goldman J, Ward K: Parainfluenza virus 3 infection after stem cell transplant: relevance to outcome of rapid diagnosis and ribavirin treatment. Clin Infect Dis. 2001, 32 (3): 413-418. 10.1086/318498.PubMedView ArticleGoogle Scholar
- Milano F, Campbell AP, Guthrie KA, Kuypers J, Englund JA, Corey L, Boeckh M: Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients. Blood. 2010, 115 (10): 2088-2094. 10.1182/blood-2009-09-244152.PubMed CentralPubMedView ArticleGoogle Scholar
- Tomblyn M, Chiller T, Einsele H, Gress R, Sepkowitz K, Storek J, Wingard JR, Young JA, Boeckh MJ: Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant. 2009, 15 (10): 1143-1238. 10.1016/j.bbmt.2009.06.019.PubMed CentralPubMedView ArticleGoogle Scholar
- Chemaly RF, Ghosh S, Bodey GP, Rohatgi N, Safdar A, Keating MJ, Champlin RE, Aguilera EA, Tarrand JJ, Raad II: Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center. Medicine (Baltimore). 2006, 85 (5): 278-287. 10.1097/01.md.0000232560.22098.4e.View ArticleGoogle Scholar
- Boeckh M, Englund J, Li Y, Miller C, Cross A, Fernandez H, Kuypers J, Kim H, Gnann J, Whitley R: Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients. Clin Infect Dis. 2007, 44 (2): 245-249. 10.1086/509930.PubMedView ArticleGoogle Scholar
- DeVincenzo JP, Hirsch RL, Fuentes RJ, Top FJ: Respiratory syncytial virus immune globulin treatment of lower respiratory tract infection in pediatric patients undergoing bone marrow transplantation - a compassionate use experience. Bone Marrow Transplant. 2000, 25 (2): 161-165. 10.1038/sj.bmt.1702118.PubMedView ArticleGoogle Scholar
- de Fontbrune FS, Robin M, Porcher R, Scieux C, de Latour RP, Ferry C, Rocha V, Boudjedir K, Devergie A, Bergeron A: Palivizumab treatment of respiratory syncytial virus infection after allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2007, 45 (8): 1019-1024. 10.1086/521912.PubMedView ArticleGoogle Scholar
- Boeckh M, Berrey MM, Bowden RA, Crawford SW, Balsley J, Corey L: Phase 1 evaluation of the respiratory syncytial virus-specific monoclonal antibody palivizumab in recipients of hematopoietic stem cell transplants. J Infect Dis. 2001, 184 (3): 350-354. 10.1086/322043.PubMedView ArticleGoogle Scholar
- Vu D, Peck AJ, Nichols WG, Varley C, Englund JA, Corey L, Boeckh M: Safety and tolerability of oseltamivir prophylaxis in hematopoietic stem cell transplant recipients: a retrospective case–control study. Clin Infect Dis. 2007, 45 (2): 187-193. 10.1086/518985.PubMedView ArticleGoogle Scholar
- Englund JA, Champlin RE, Wyde PR, Kantarjian H, Atmar RL, Tarrand J, Yousuf H, Regnery H, Klimov AI, Cox NJ: Common emergence of amantadine- and rimantadine-resistant influenza A viruses in symptomatic immunocompromised adults. Clin Infect Dis. 1998, 26 (6): 1418-1424. 10.1086/516358.PubMedView ArticleGoogle Scholar
- Klimov AI, Rocha E, Hayden FG, Shult PA, Roumillat LF, Cox NJ: Prolonged shedding of amantadine-resistant influenzae A viruses by immunodeficient patients: detection by polymerase chain reaction-restriction analysis. J Infect Dis. 1995, 172 (5): 1352-1355. 10.1093/infdis/172.5.1352.PubMedView ArticleGoogle Scholar
- Johny AA, Clark A, Price N, Carrington D, Oakhill A, Marks DI: The use of zanamivir to treat influenza A and B infection after allogeneic stem cell transplantation. Bone Marrow Transplant. 2002, 29 (2): 113-115. 10.1038/sj.bmt.1703343.PubMedView ArticleGoogle Scholar
- Fraaij PL, van der Vries E, Beersma MF, Riezebos-Brilman A, Niesters HG, van der Eijk AA, de Jong MD, Reis MD, Horrevorts AM, Ridwan BU: Evaluation of the antiviral response to zanamivir administered intravenously for treatment of critically ill patients with pandemic influenza A (H1N1) infection. J Infect Dis. 2011, 204 (5): 777-782. 10.1093/infdis/jir397.PubMed CentralPubMedView ArticleGoogle Scholar
- Ljungman P, de la Camara R, Perez-Bercoff L, Abecasis M, Nieto CJ, Cannata-Ortiz MJ, Cordonnier C, Einsele H, Gonzalez-Vicent M, Espigado I: Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients. Haematologica. 2011, 96 (8): 1231-1235. 10.3324/haematol.2011.041913.PubMed CentralPubMedView ArticleGoogle Scholar
- Williams JV, Martino R, Rabella N, Otegui M, Parody R, Heck JM, Crowe JJ: A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections. J Infect Dis. 2005, 192 (6): 1061-1065. 10.1086/432732.PubMed CentralPubMedView ArticleGoogle Scholar
- La Rosa AM, Champlin RE, Mirza N, Gajewski J, Giralt S, Rolston KV, Raad I, Jacobson K, Kontoyiannis D, Elting L: Adenovirus infections in adult recipients of blood and marrow transplants. Clin Infect Dis. 2001, 32 (6): 871-876. 10.1086/319352.PubMedView ArticleGoogle Scholar
- Bordigoni P, Carret AS, Venard V, Witz F, Le Faou A: Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2001, 32 (9): 1290-1297. 10.1086/319984.PubMedView ArticleGoogle Scholar
- Liles WC, Cushing H, Holt S, Bryan C, Hackman RC: Severe adenoviral nephritis following bone marrow transplantation: successful treatment with intravenous ribavirin. Bone Marrow Transplant. 1993, 12 (4): 409-412.PubMedGoogle Scholar
- Chakrabarti S, Collingham KE, Fegan CD, Milligan DW: Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy. Bone Marrow Transplant. 1999, 23 (11): 1209-1211. 10.1038/sj.bmt.1701788.PubMedView ArticleGoogle Scholar
- Sivaprakasam P, Carr TF, Coussons M, Khalid T, Bailey AS, Guiver M, Mutton KJ, Turner AJ, Grainger JD, Wynn RF: Improved outcome from invasive adenovirus infection in pediatric patients after hemopoietic stem cell transplantation using intensive clinical surveillance and early intervention. J Pediatr Hematol Oncol. 2007, 29 (2): 81-85. 10.1097/MPH.0b013e318030875e.PubMedView ArticleGoogle Scholar
- Feuchtinger T, Matthes-Martin S, Richard C, Lion T, Fuhrer M, Hamprecht K, Handgretinger R, Peters C, Schuster FR, Beck R: Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol. 2006, 134 (1): 64-76. 10.1111/j.1365-2141.2006.06108.x.PubMedView ArticleGoogle Scholar
- Regn S, Raffegerst S, Chen X, Schendel D, Kolb HJ, Roskrow M: Ex vivo generation of cytotoxic T lymphocytes specific for one or two distinct viruses for the prophylaxis of patients receiving an allogeneic bone marrow transplant. Bone Marrow Transplant. 2001, 27 (1): 53-64. 10.1038/sj.bmt.1702752.PubMedView ArticleGoogle Scholar
- Roddie C, Paul JP, Benjamin R, Gallimore CI, Xerry J, Gray JJ, Peggs KS, Morris EC, Thomson KJ, Ward KN: Allogeneic hematopoietic stem cell transplantation and norovirus gastroenteritis: a previously unrecognized cause of morbidity. Clin Infect Dis. 2009, 49 (7): 1061-1068. 10.1086/605557.PubMedView ArticleGoogle Scholar
- Endo T, Sakai T, Fujimoto K, Yamamoto S, Takashima H, Haseyama Y, Nishio M, Koizumi K, Koike T, Sawada K: A possible role for lamivudine as prophylaxis against hepatitis B reactivation in carriers of hepatitis B who undergo chemotherapy and autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma. Bone Marrow Transplant. 2001, 27 (4): 433-436. 10.1038/sj.bmt.1702804.PubMedView ArticleGoogle Scholar
- Lau GK, Liang R, Wu PC, Lee CK, Lim WL, Au WY: Use of famciclovir to prevent HBV reactivation in HBsAg-positive recipients after allogeneic bone marrow transplantation. J Hepatol. 1998, 28 (3): 359-368. 10.1016/S0168-8278(98)80307-3.PubMedView ArticleGoogle Scholar
- Ljungman P, Andersson J, Aschan J, Bjorkstrand B, Hagglund H, Lonnqvist B, Ringden O, Winiarski J: Oral ribavirin for prevention of severe liver disease caused by hepatitis C virus during allogeneic bone marrow transplantation. Clin Infect Dis. 1996, 23 (1): 167-169. 10.1093/clinids/23.1.167.PubMedView ArticleGoogle Scholar
- Giardini C, Galimberti M, Lucarelli G, Polchi P, Angelucci E, Baronciani D, Erer B, Gaziev D, Piga A, Di Gregorio F: Alpha-interferon treatment of chronic hepatitis C after bone marrow transplantation for homozygous beta-thalassemia. Bone Marrow Transplant. 1997, 20 (9): 767-772. 10.1038/sj.bmt.1700968.PubMedView ArticleGoogle Scholar
- Ljungman P, Johansson N, Aschan J, Glaumann H, Lonnqvist B, Ringden O, Sparrelid E, Sonnerborg A, Winiarski J, Gahrton G: Long-term effects of hepatitis C virus infection in allogeneic bone marrow transplant recipients. Blood. 1995, 86 (4): 1614-1618.PubMedGoogle Scholar
- Balduzzi A, Lucchini G, Hirsch HH, Basso S, Cioni M, Rovelli A, Zincone A, Grimaldi M, Corti P, Bonanomi S: Polyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipient. Bone Marrow Transplant. 2011, 46 (7): 987-992. 10.1038/bmt.2010.221.PubMedView ArticleGoogle Scholar
- Leung AY, Chan MT, Yuen KY, Cheng VC, Chan KH, Wong CL, Liang R, Lie AK, Kwong YL: Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2005, 40 (4): 528-537. 10.1086/427291.PubMedView ArticleGoogle Scholar
- Bridges B, Donegan S, Badros A: Cidofovir bladder instillation for the treatment of BK hemorrhagic cystitis after allogeneic stem cell transplantation. Am J Hematol. 2006, 81 (7): 535-537. 10.1002/ajh.20567.PubMedView ArticleGoogle Scholar
- Savona MR, Newton D, Frame D, Levine JE, Mineishi S, Kaul DR: Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant. Bone Marrow Transplant. 2007, 39 (12): 783-787. 10.1038/sj.bmt.1705678.PubMedView ArticleGoogle Scholar
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