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  1. Research

    A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia

    Hepcidin plays a central role in iron homeostasis and erythropoiesis. Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin internalization, restore iron efflux from cells, and allow t...

    Saroj Vadhan-Raj, Rafat Abonour, Jonathan W. Goldman, David A. Smith, Christopher A. Slapak, Robert L. Ilaria, Ramon V. Tiu, Xuejing Wang, Sophie Callies, Joanne Cox, Jay L. Tuttle, Yiu-Keung Lau and Eric J. Roeland

    Journal of Hematology & Oncology 2017 10:73

    Published on: 21 March 2017

  2. Research

    Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis

    Polymeric fibronectin (polyFN) assembled on suspended breast cancer cells is required for metastasis. Conceivably, drugs that target such polyFN may fight against cancer metastasis. While stilbene analogs trig...

    Ying-Jan Wang, Jing-Fang Lin, Li-Hsin Cheng, Wen-Tsan Chang, Ying-Hsien Kao, Ming-Min Chang, Bour-Jr Wang and Hung-Chi Cheng

    Journal of Hematology & Oncology 2017 10:72

    Published on: 21 March 2017

  3. Letter to the Editor

    A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety

    Melittin is the main effective component of bee venom and has extensive biological functions; however, serious side effects have restricted its clinical application. Preclinical and clinical studies showed tha...

    Jie Mao, Shujun Liu, Min Ai, Zhuo Wang, Duowei Wang, Xianjing Li, Kaiyong Hu, Xinghua Gao and Yong Yang

    Journal of Hematology & Oncology 2017 10:71

    Published on: 20 March 2017

  4. Rapid communication

    Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort

    Recently, the mutational background of diffuse large B cell lymphoma (DLBCL) has been revealed, identifying specific genetic events that drive lymphomagenesis. However, the prognostic value of these mutations ...

    Darius Juskevicius, David Jucker, Dirk Klingbiel, Christoph Mamot, Stephan Dirnhofer and Alexandar Tzankov

    Journal of Hematology & Oncology 2017 10:70

    Published on: 17 March 2017

  5. Letter to the Editor

    Chidamide in relapsed or refractory peripheral T cell lymphoma: a multicenter real-world study in China

    The efficacy and safety of chidamide, a new subtype-selective histone deacetylase (HDAC) inhibitor, have been demonstrated in a pivotal phase II clinical trial, and chidamide has been approved by the China Foo...

    Yuankai Shi, Bo Jia, Wei Xu, Wenyu Li, Ting Liu, Peng Liu, Weili Zhao, Huilai Zhang, Xiuhua Sun, Haiyan Yang, Xi Zhang, Jie Jin, Zhengming Jin, Zhiming Li, Lugui Qiu, Mei Dong…

    Journal of Hematology & Oncology 2017 10:69

    Published on: 15 March 2017

  6. Rapid communication

    Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells

    Multiple iterations of chimeric antigen receptors (CARs) have been developed, mainly focusing on intracellular signaling modules. However, the effect of non-signaling extracellular modules on the expansion and...

    Le Qin, Yunxin Lai, Ruocong Zhao, Xinru Wei, Jianyu Weng, Peilong Lai, Baiheng Li, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Yangqiu Li, Xuchao Zhang, Yilong Wu, Pentao Liu, Yao Yao…

    Journal of Hematology & Oncology 2017 10:68

    Published on: 13 March 2017

  7. Review

    T-ALL and thymocytes: a message of noncoding RNAs

    In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic...

    Annelynn Wallaert, Kaat Durinck, Tom Taghon, Pieter Van Vlierberghe and Frank Speleman

    Journal of Hematology & Oncology 2017 10:66

    Published on: 7 March 2017

  8. Letter to the Editor

    Mutational profiling of acute lymphoblastic leukemia with testicular relapse

    Relapsed acute lymphoblastic leukemia (ALL) is the leading cause of deaths of childhood cancer. Although relapse usually happens in the bone marrow, extramedullary relapse occasionally occurs including either ...

    Ling-Wen Ding, Qiao-Yang Sun, Anand Mayakonda, Kar-Tong Tan, Wenwen Chien, De-Chen Lin, Yan-Yi Jiang, Liang Xu, Manoj Garg, Zhen-Tang Lao, Michael Lill, Henry Yang, Allen Eng Juh Yeoh and H. Phillip Koeffler

    Journal of Hematology & Oncology 2017 10:65

    Published on: 2 March 2017

  9. Review

    Uncovering the roles of long non-coding RNAs in cancer stem cells

    Cancer has been a major public health problem that has threatened human life worldwide throughout history. The main causes that contribute to the poor prognosis of cancer are metastasis and recurrence. Cancer ...

    Xiaoxing Huang, Ruijing Xiao, Shan Pan, Xiangyong Yang, Wen Yuan, Zhenbo Tu, Ming Xu, Yufan Zhu, Qian Yin, Yingjie Wu, Weidong Hu, Liang Shao, Jie Xiong and Qiuping Zhang

    Journal of Hematology & Oncology 2017 10:62

    Published on: 28 February 2017

  10. Letter to the Editor

    A hybrid of B and T lymphoblastic cell line could potentially substitute dendritic cells to efficiently expand out Her-2/neu-specific cytotoxic T lymphocytes from advanced breast cancer patients in vitro

    Adoptive transfer of cytotoxic T lymphocytes (CTLs) holds promises to cure cancer. However, this treatment is hindered by lacking a robust way to specifically expand out CTLs. Here, we developed a hybrid of B ...

    Sheng Chen, Feifei Gu, Kang Li, Kai Zhang, Yangyang Liu, Jinyan Liang, Wei Gao, Gang Wu and Li Liu

    Journal of Hematology & Oncology 2017 10:63

    Published on: 28 February 2017

  11. Case report

    Severe nivolumab-induced pneumonitis preceding durable clinical remission in a patient with refractory, metastatic lung squamous cell cancer: a case report

    Programmed cell death 1 (PD-1) and its ligand 1 (PD-L1) inhibitors have quickly become standard of care for patients with advanced non-small cell lung cancer and increasing numbers of other cancer types. In th...

    Hong Li, Weijie Ma, Ken Y. Yoneda, Elizabeth H. Moore, Yanhong Zhang, Lee L. Q. Pu, Garrett M. Frampton, Michael Molmen, Philip J. Stephens and Tianhong Li

    Journal of Hematology & Oncology 2017 10:64

    Published on: 28 February 2017

  12. Letter to the Editor

    Spectrum of somatic mutations detected by targeted next-generation sequencing and their prognostic significance in adult patients with acute lymphoblastic leukemia

    Target-specific next-generation sequencing technology was used to analyze 112 genes in adult patients with acute lymphoblastic leukemia (ALL). This sequencing mainly focused on the specific mutational hotspots...

    Juan Feng, Yan Li, Yujiao Jia, Qiuyun Fang, Xiaoyuan Gong, Xiaobao Dong, Kun Ru, Qinghua Li, Xingli Zhao, Kaiqi Liu, Min Wang, Zheng Tian, Yannan Jia, Ying Wang, Dong Lin, Hui Wei…

    Journal of Hematology & Oncology 2017 10:61

    Published on: 28 February 2017

  13. Research

    Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

    An increased expression of Yes-associated protein (YAP1) has been shown to promote tumorigenesis in many cancer types including colon. However, the role of YAP1 in promoting colon tumorigenesis remains unclear...

    Yan-Jiun Huang, Ching-Kuo Yang, Po-Li Wei, Thanh-Tuan Huynh, Jacqueline Whang-Peng, Tzu-Ching Meng, Michael Hsiao, Yew-Ming Tzeng, Alexander TH Wu and Yun Yen

    Journal of Hematology & Oncology 2017 10:60

    Published on: 28 February 2017

  14. Research

    Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1

    Arsenic trioxide (ATO) is commonly used in the treatment of acute promyelocytic leukemia (APL), but does not benefit patients with solid tumors. When combined with other agents or radiation, ATO showed treatme...

    Sunbin Ling, Haiyang Xie, Fan Yang, Qiaonan Shan, Haojiang Dai, Jianyong Zhuo, Xuyong Wei, Penghong Song, Lin Zhou, Xiao Xu and Shusen Zheng

    Journal of Hematology & Oncology 2017 10:59

    Published on: 28 February 2017

  15. Review

    Extracellular vesicles-mediated noncoding RNAs transfer in cancer

    Extracellular vesicles (EVs) are small membranous vesicles secreted from numerous cell types and have been found involved in cell-to-cell communication by transferring noncoding RNAs (ncRNAs) including microRN...

    Pei Ma, Yutian Pan, Wei Li, Chongqi Sun, Jie Liu, Tongpeng Xu and Yongqian Shu

    Journal of Hematology & Oncology 2017 10:57

    Published on: 23 February 2017

  16. Research

    Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor d-1-methyl-tryptophan

    Although blinatumomab, a bispecific T cell engaging antibody, exhibits high clinical response rates in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (B-ALL) and B cell non-Hodgk...

    Xiaolong Zhang, Yuanyuan Yang, Leisheng Zhang, Yang Lu, Qing Zhang, Dongmei Fan, Yizhi Zhang, Yanjun Zhang, Zhou Ye and Dongsheng Xiong

    Journal of Hematology & Oncology 2017 10:56

    Published on: 23 February 2017

  17. Research

    Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia vera

    The driver mutations JAK2V617F, MPLW515L/K and CALR influence disease phenotype of myeloproliferative neoplasms (MPNs) and might sustain a condition of chronic inflammation. Pentraxin 3 (PTX3) and high-sensitivit...

    Federico Lussana, Alessandra Carobbio, Silvia Salmoiraghi, Paola Guglielmelli, Alessandro Maria Vannucchi, Barbara Bottazzi, Roberto Leone, Alberto Mantovani, Tiziano Barbui and Alessandro Rambaldi

    Journal of Hematology & Oncology 2017 10:54

    Published on: 22 February 2017

  18. Research

    Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial

    The randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial evaluated the JAK1/JAK2 inhibitor ruxolitinib in patients with intermediate-2/high-risk myelofibrosis. The primary and planned 3-year a...

    Srdan Verstovsek, Ruben A. Mesa, Jason Gotlib, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael W. N. Deininger, Carole B. Miller, Richard T. Silver, Moshe Talpaz, Elliott F. Winton, Jimmie H. Harvey, Murat O. Arcasoy, Elizabeth O. Hexner, Roger M. Lyons, Ronald Paquette…

    Journal of Hematology & Oncology 2017 10:55

    Published on: 22 February 2017

  19. Review

    New development in CAR-T cell therapy

    Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-...

    Zhenguang Wang, Zhiqiang Wu, Yang Liu and Weidong Han

    Journal of Hematology & Oncology 2017 10:53

    Published on: 21 February 2017

  20. Review

    Paxillin: a crossroad in pathological cell migration

    Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell mov...

    Ana María López-Colomé, Irene Lee-Rivera, Regina Benavides-Hidalgo and Edith López

    Journal of Hematology & Oncology 2017 10:50

    Published on: 18 February 2017

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