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Table 1 Reports of antiandrogen withdrawal

From: A dramatic, objective antiandrogen withdrawal response: case report and review of the literature

Author Antiandrogen agent(s) No. of Patients No. of patients with 50% PSA decline Duration of Anti-androgen therapy (Months) Duration of AAWR (Months)
Kelly[5] Flutamide 3 2 5–17 2–5
Collinson[17] Flutamide 1 1 12 12
Scher[6] Flutamide 36 10 NS 5*
Scher[15] Flutamide 57 16 16 5.6
Dupont[7] Flutamide† 40 32 5–7 14.5
Figg[16] Flutamide 21 7 28 3.7
Sartor[18] Flutamide† 29 14 Median: 27* 8
Herrade[8] Flutamide 39 11 Median: 19* 3.3
Small[9] Flutamide 82 12 Median: 21.5* 3.5
Small[10] Bicalutamide 1 1 32 2
Nieh[19] Bicalutamide 3 2 24–35 2–4
Schellhammer [11] Flutamide/Bicalutamide‡ 22 8 16 months combined with LHRH agonist NS
Small[14] Flutamide/Bicalutamide/Nilutamide 132 15 NS 5.9
Gomella[12] Nilutamide 1 1 11 3
Huan[13] Nilutamide†† 2 2 10 and 15 7 and 6
  1. NS = not stated
  2. * indicates median
  3. † Adjuvant treatment with aminoglutamide and hydrocortisone
  4. ‡ 4 patients assessed for objective response at 12 weeks: 2 has stable disease
  5. †† One patient was treated with flutamide, and then cyproterone before nilutamide; Another patient were treated with combined goserelin and nilutamide