Figure 5

PHI inhibits production of VEGF in RPMI8226 myeloma cells. (A). The cells were incubated with varying concentration of PHI for 24 and 48 hours, respectively. VEGF production was determined as described in the Material and Methods. Diamond (♦), control; Square (■), 0.1 μM; Triangle (), 5 μM; Cross (x), 10 μM. (B). Percent inhibition of VEGF production as compared with the control culture was calculated from the above experiments. Values are means +/- SD from 3 independent experiments. Open bar, 24 hours; Black bar, 48 hours.