Isolation of specific and biologically active peptides that bind cells from patients with acute myeloid leukemia (AML)

Table 5 Clinical characteristics of AML patients at the time the bone marrow was obtained and biological response after 14 days of culture in the presence of GM-CSF (100 U/ml) or one peptide (10^-4 M).

Patient number	Age	FAB	Blast Count	Karyotype Abnormalities	Prior MDS	Prior Toxic Exposure	Increase in colony number		Decrease in colony number		Differentiation
							peptide	GM-CSF	peptide	GM-CSF	peptide	GM-CSF
15857	76	M0	20	yes	yes		-	-	+^A	-	+	+
14742	58	M0	88	no	no	yes	-	-	-	-	ND	ND
14924	76	M1	8		yes		+	+	-	-	-	-
16249		M1	77				+	-	-	-	-	-
14372	56	M1	49	no	yes	yes	+	+	-	-	-	-
14122	72	M1	63	yes	yes	yes	+	+	-	-	ND	ND
15492	45	M1	55	no	no	yes	-	+	+	-	+	-
15480	55	M1	88		no	yes	-	ND	-	ND	-	ND
14373	66	M1	69	yes	yes		+	+	+	-	+	+
15071	66	M1	27	no	yes		-	-	-	-	-	-
15019	77	M2	34	no	yes	no	+	+	-	-	+	+
15891	58	M2	52	yes			-	+	-	-	+	+
16313	48	M2	38	no	no	no	+	-	-	-	+	+
11369	33	M2	20	yes	yes	yes	-	-	-	-	ND	ND
14996	48	M3		yes	no	no	-	-	-	-	ND	ND
16352	74	M4	34	yes	yes	no	+	-	+	-	+	-
16278	25	M4	35		no	no	+	+	-	-	+	-
14499	74	Unclas-sified	3			no	-	+	+	-	+	+
13459	59	Un-known	80		no	yes	+	+	-	-	-	-

^A A modification of cell behavior in response to GM-CSF or to at least one peptide is noted +

ISSN: 1756-8722