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Table 3 Immunohistochemical and molecular features of 50 cases of ALK-DLBCL reported in the literature

From: ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature

  Number studied Number positive/weak %
Immunohistochemistry    
   ALK 50 50 100
Cytoplasmic   43 86
Nuclear   6 12
Other   1 2
   VS38c/CD138/MUM1 39 39 100
   EMA 38 37 97
   CD45 27 19/2 78
   CD4 40 11/5 40
   CD57 24 3/5 33
   Perforin 24 2 8
   CD20 44 4/1 11
   CD79a 44 6/2 18
   CD30 45 5 11
   EBV 17 0 0
   HHV8 2 0 0
Molecular studies    
   ALK gene rearrangement 24 24 100
Clathrin/ALK   18 75
Nucleophosmin/ALK   4 16
Other rearrangements   2 8
   IgH gene rearrangement 20 17 85
   TCR gene rearrangement 4 1 25
   EBER CISH 12 0 0
  1. ALK – anaplastic lymphoma kinase
  2. EMA – epithelial membrane antigen
  3. EBV – Epstein Barr virus
  4. HHV8 – human herpesvirus 8
  5. IgH – immunoglobulin heavy chain
  6. TCR – T-cell receptor
  7. EBER – EBV-encoded RNA
  8. CISH – chromogenic in situ hybridization