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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra®, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

Figure 1

Ezatiostat HCl Liposomes for Injection (TLK199) Mechanism of Action. 1. Esterase action on the diester prodrug, ezatiostat liberates the active moiety, the tripeptide diacid; 2. Binding of diacid to GST P1-1 leads to release of JNK; 3. JNK phosphorylated c-JUN; 4. Phosphorylated C-Jun translocates to the nucleus and participates in transcription of growth and differentiation genes; 5. Trilineage growth and differentiation results.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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