Table 1 Genetic Abnormalities in Normal Cytogenetic AML
From: Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics
Name | Prognosis | Prevalence | Expression |
|---|---|---|---|
NPM-1 | Favorable | 50–60% | Mutation |
FLT3-ITD | Unfavorable | 30–40% | Mutation |
FLT3-Asp835 | Unclear | 5–10% | Mutation |
BAALC | Unfavorable | 65.7% | Over expression |
MN1 | Unfavorable | 50% | Over expression |
MLL-PTD | Unfavorable | 7.7% | Mutation/over expression |
CEBPα | Favorable | 15–20% | Mutation |
ERG-1 | Unfavorable | 25% | Over expression |
AF1q | Unfavorable | 75% | Over expression |