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Figure 3 | Journal of Hematology & Oncology

Figure 3

From: RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression

Figure 3

Effect of RIZ1 expression on cell viability and apoptosis in CML myeloid blast crisis model cell lines. (a) Viability assay for cell lines transfected with pRIZ1 (dashed line) or pcDNA3 control plasmid (solid line). (b) Annexin V assay of ERY-1, YN-1, JURL-MK1, and K562 one day after transfection with pRIZ1 (+) or pcDNA3 control plasmid (-). Percentages of apoptotic cells were detected using annexin V-FITC and PI staining. Total percentage of cells undergoing early and end stage apoptosis are indicated. White histogram represents cells in early apoptosis (FITC+, PI-). Black histogram represents cells that are in the end stage of apoptosis or that are already dead (FITC+, PI+). Error bars represent standard deviation from three independent experiments.

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