Inhibition of CSF1-primed LPS-induced TNF release. Mice were given ABT-869 (PO) at the indicated dose and 45 minutes later primed with CSF1 (1.8 μg IP). After 3.25 hours, LPS (300 μg IP) was administered. Serum TNF, expressed as mean ± SEM (n = 6), was assessed 1.5 hours later. CSF1 increased serum TNF induced by LPS by >4 fold (8 vs 37 ng/mL).