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Table 2 Current listed clinical trials on ABT-869

From: ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside

Trial title Enrollment Trial design Last verified Recruitment Start date
Phase 2 Study of ABT-869 in Combination With Paclitaxel Versus Paclitaxel Alone as First Line Treatment For Metastatic Breast Cancer 102 RDBT, MC April 2009 Recruiting March 2008
Phase 2 Study of ABT-869 in Advanced Hepatocellular Carcinoma (HCC) 44 RDBT, MC March 2009 Active, not recruiting August 2007
Study of ABT-869 in Combination With Tarceva in Subjects With Solid Tumors 0 W January 2009 Withdrawn September 2008
Phase 1 Study of ABT-869 in Subjects With Solid Tumors 24 Conducted in Japan March 2009 Recruiting September 2008
Phase 2 Study of ABT-869 in Subjects With Advanced Non-Small Cell Lung Cancer (NSCLC) 139 RUO, MC March 2009 Active, not recruiting August 2007
Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 as Second Line Treatment for Advanced Colorectal Cancer 102 RUO, MC April 2009 Recruiting August 2008
Phase 2 Study of Carboplatin/Paclitaxel in Combination With ABT-869 in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) 80 RDBT, MC April 2009 Recruiting June 2008
Phase 2 Study of ABT-869 in Subjects With Advanced Renal Cell Carcinoma Who Have Previously Received Treatment With Sunitinib 53 Open label, NR April 2009 Active, not recruiting August 2007
Phase 2 Study of Oxaliplatin, Fluorouracil, Leucovorin and ABT-869 or Bevacizumab as Second-Line Therapy in Treating Patients With Locally Recurrent or Metastatic Colorectal Cancer 0 Single center October 2008 Not yet recruiting October 2008
Phase 1 Pharmacokinetic Study To Evaluate Effect of Food and Diurnal Variation on ABT-869 12 Single center March 2009 Recruiting February 2009
  1. Data compiled from http://www.clinicaltrials.org
  2. RDBT: Randomized, placebo-controlled, double blind trial
  3. MC: Multicenter
  4. W: Withdrawn prior to recruitment
  5. RUO: Randomized, uncontrolled, open label
  6. NR: Non-Randomized