Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma

Table 1 Relative expression of APPs in the sera of patients in different clinical stages of EOCa.

Serum proteins	*Fold changes and statistical significance				Probability P
	Stage I	Stage II	Stage III	Stage IV
CLU	#	#	nd	nd	0.0004
LRG	+23.36-fold; p = 0.0001	+16.46-fold; p = 0.0001	+6.44-fold; p = 0.0001	+15.34-fold; p = 0.0128	0.0001
ACT	+2.65-fold; p = 0.0001	+3.94-fold; p = 0.0006	+5.50-fold; p = 0.0001	ns	0.2177
HAP	+2.24-fold; p = 0.0001	+2.84-fold; p = 0.0004	+6.78-fold; p = 0.0001	ns	0.0001
AAT	+2.52-fold;p = 0.0001	+3.35-fold;p = 0.0001	+4.09-fold;p = 0.0001	+4.75-fold;p = 0.0001	0.0008
HAPc	#	#	#	#	0.0757
AATf	+7.30-fold; p = 0.0001	+8.91-fold; p = 0.0001	+8.12-fold; p = 0.0001	+14.14-fold; p = 0.0001	0.0388

*Fold change measures the degree of change in protein expression in patients compared to that of negative controls. This is measured by dividing the average spot intensity in the patients by average spot intensity in the control.
# exclusive detection in patients (not detected in negative controls)
ns protein not significantly expressed
nd protein not detected
+ increased in expression
-- decreased in expression

ISSN: 1756-8722