Figure 4

Probability of first remission duration of AML patients in relation to the growth patterns of their leukemic blasts in SCID mice. Patients (newly diagnosed or relapsed, n = 20) whose leukemic cells grew aggressively had a poor clinical outcome. In contrast, patients whose leukemic blasts displayed either no tumor growth or an indolent growth at initial presentation (n = 22) had a favorable clinical outcome. Patients whose leukemic blasts displayed no tumor growth or an indolent pattern at relapse (n = 10) also had a poor out come.