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Table 1 Phase II studies incorporating targeted agents in advanced gastroesophageal cancer

From: Recent advances in gastrointestinal oncology - updates and insights from the 2009 annual meeting of the American Society of Clinical Oncology

Targeted agent

Chemotherapy

N

RR

PFS (months)

OS (months)

Reference

Cetuximab

Irinotecan and FU

49

42%

8.6

16.6

Kanzler et al. [11]

Bevacizumab

Docetaxel, FU and cisplatin

44

67%

12

16.2

Kelsen et al. [12]

Cetuximab

Irinotecan and oxaliplatin

51

60%

6

9.5

Woell et al. [13]

  1. N: patient number; RR: response rate; PFS: progression-free survival; OS: overall survival; FU: 5-fluorouracil