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Table 3 Farnesyl-transferase inhibitor in clinical trials

From: Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights

inhibitors Other agents Disease Dosage Clinical trails No Pts Response Reference
Tipifarnib Bortezomib
1.0 mg/m2
Elderly or relapsed AML 300-600 mg bid, ×21d Phase II 80 CR: 11% [30]
Tipifarnib +/- etoposide Elderly untreated AML   Phase II 107 Safe [31]