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Table 5 PFS and OS in Zodiac, Zeal, and Zest studies.

From: Updates in non-small cell lung cancer - insights from the 2009 45th annual meeting of the American Society of Clinical Oncology

TRIAL

Zodiac

Zeal

Zest

Treatment

Vandetanib+Docetaxel

Placebo+Docetaxel

Vandetanib+Pemetrexed

Placebo+Pemetrexed

Vandetanib

Erlotinib

Median PFS

4.0 Months

3.2 Months

17.6 Weeks

11.9 Weeks

11.3 Weeks

8.9 Weeks

HR

0.79

0.91

0.86

0.86

0.98

1.01

P-Value

< 0.001

0.196

0.108

0.22

0.72

0.83

Median OS Months

10.6

10.0

10.5

9.2

6.9

7.8

  1. PFS, progression free survival; OS, overall survival; HR, hazard ratio;
  2. Reference: [34–36]