Table 1 Cutaneous manifestations of internal malignancies
From: Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers
Cutaneous feature | Clinical findings | Associated malignancy |
|---|---|---|
Acanthosis nigricans (malignant) | Velvety hyperpigmented thickening extending beyond the flexures and neck to involve lips, palms | Intra-abdominal adenocarcinoma, lung carcinoma, lymphoreticular malignancies |
Acrokeratosis paraneoplastica (Bazex's syndrome) | Psoriasiform dermatitis with nail dystrophy affecting hands, feet, ears, nose | Squamous cell carcinoma of upper aerodigestive tract |
Erythema gyratum repens | Wood grain pattern annular, scaling erythema | Lung carcinoma |
Necrolytic migratory erythema | Eroded erythematous annular polycyclic eruption affecting intertriginous areas | Glucagonoma |
Sweet syndrome | Plum coloured nodules affecting head, neck and dorsae, hands | Can be associated with leukaemia, lymphoma, multiple myeloma |
Pyoderma gangrenosum especially bullous variant | Painful inflammatory ulcers with raised violaceous edge and overhanging borders; associated pathergy | Can be associated with leukaemia, lymphoma, multiple myeloma |
Paraneoplastic pemphigus | Bullous, erosive mucosal +/- cutaneous eruption | Haematologic malignancies, thymoma |
Necrobiotic xanthogranuloma | Purpuric yellow plaques in periorbital and flexural areas | Monoclonal gammopathy/multiple myeloma |
Diffuse plane xanthomas | Yellow-orange macules and plaques | Monoclonal gammopathy/multiple myeloma |
Scleromyxoedema | Scleroderma-like thickening of skin associated with coloured skin or erythematous papular infiltrate | Monoclonal gammopathy/multiple myeloma |
Primary systemic amyloidosis | Macroglossia, purpura especially periorbital and infiltrated papules | Monoclonal gammopathy/multiple myeloma |