Table 1 Baseline and transplant characteristics of patients in Bu/Cy and t-IV Bu/Flu groups
Variables | Bu/Cy (Freq/Percent) | Bu/Flu (Freq/Percent) | Total (Freq) | P-value | |
|---|---|---|---|---|---|
Name | Level | ||||
Time from diagnosis to HCT | Months (median value, range) | 6.2 (1-29) | 6.4 (2-54) | 0.5 | |
Follow up time | Months (median value, range) | 8 (1-90) | 17 (1-53) | 0.245 | |
Donor | MRD | 51 100.00 | 39 39.00 | 81 | < .0001 |
MUD | 0 0.00 | 39 39.00 | 39 | ||
MMUD | 0 0.00 | 22 22.00 | 22 | ||
Cytogenetic | Low | 3 7.89 | 7 7.00 | 10 | 0.3568 |
Intermediate | 25 65.79 | 54 54.00 | 79 | ||
High | 10 26.32 | 39 39.00 | 49 | ||
ATG | No | 42 100.00 | 78 78.79 | 120 | 0.0006 |
Yes | 0 0.00 | 20 20.20 | 20 | ||
Cell Source | BM | 35 68.63 | 2 2.00 | 37 | < .0001 |
PB | 16 31.37 | 98 98.00 | 114 | ||
aGVHD prophylaxis | CSA/MTX | 51 100.00 | 0 0.00 | 42 | < .0001 |
TAC/MMF | 0 0.00 | 22 22.00 | 22 | ||
TAC/MTX | 0 0.00 | 77 71.00 | 77 | ||
TAC/RAPA | 0 0.00 | 1 1.00 | 1 | ||
Disease Status | CR1 | 19 37.25 | 49 49.00 | 68 | 0.0013 |
CR2 or CR3 | 6 11.76 | 25 25.00 | 31 | ||
PIF | 7 13.73 | 16 16.00 | 23 | ||
Relapse | 18 35.29 | 9 9.00 | 27 | ||
UNT | 1 1.96 | 1 1.00 | 2 | ||
Diagnosis | primary | 41 80.39 | 62 62.00 | 103 | 0.0221 |
secondary | 10 19.61 | 38 38.00 | 48 | ||
No of Induction | 0 | 1 2.38 | 1 1.00 | 2 | 0.4882 |
1 | 31 73.81 | 67 67.00 | 98 | ||
2 | 9 21.43 | 24 24.00 | 33 | ||
3 | 1 2.38 | 8 8.00 | 9 | ||
AGE | 39.0 (19.6-55.60) | 48.16(21.84-68.64) | 0.0001 | ||
WBC at Diagnosis | 13.60 (0.80-190.00) | 5.80 (0.25-285.00) | 0.1073 | ||
Time in CR1 | 256 (12-762) | 324.5 (21 - 2679) | 0.1699 | ||
% Blast in BM | 4 (0 - 88) | 2 (0-80) | 0.0028 | ||
Chimerism (day 90) | BM | 100 (55-100) | 97 (10-100) | 0.0925 | |
CD3 | NA | 90 (18-100) | NA | ||
CD33 | NA | 100 (10-100) | NA | ||