Strategy | Modulator | Delivery | Clinical Utility | References |
---|---|---|---|---|
Inhibition of mature microRNA cluster | microRNA sponge | Sponge plasmid vector | Silence oncomiR cluster | [60] |
Inhibition of mature microRNA | 2'OME-AMOs | RNA-Liposome Complex | Silence OncomiR | [94] |
Inhibition of mature microRNA | 2'MOE AMOs | Oligonucleotide-Liposome Complex | Silence OncomiR | |
Inhibition of pri-microRNA | AMOs | Oligonucleotide-Liposome Complex | Silence miR cluster | |
Inhibition of mature microRNA | LNA-antagomiR | Unconjugated | Silence OncomiR | [99] |
Silence selected target | Synthetic microRNAs | Conjugation | Tumor Suppressor Function |