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Table 2 Strategies to Employ MicroRNAs in the Clinic

From: The clinical potential of microRNAs

Strategy

Modulator

Delivery

Clinical Utility

References

Inhibition of mature microRNA cluster

microRNA sponge

Sponge plasmid vector

Silence oncomiR cluster

[60]

Inhibition of mature microRNA

2'OME-AMOs

RNA-Liposome Complex

Silence OncomiR

[94]

Inhibition of mature microRNA

2'MOE AMOs

Oligonucleotide-Liposome Complex

Silence OncomiR

[95, 96]

Inhibition of pri-microRNA

AMOs

Oligonucleotide-Liposome Complex

Silence miR cluster

[97, 98]

Inhibition of mature microRNA

LNA-antagomiR

Unconjugated

Silence OncomiR

[99]

Silence selected target

Synthetic microRNAs

Conjugation

Tumor Suppressor Function

[100, 101]