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Table 2 Strategies to Employ MicroRNAs in the Clinic

From: The clinical potential of microRNAs

Strategy Modulator Delivery Clinical Utility References
Inhibition of mature microRNA cluster microRNA sponge Sponge plasmid vector Silence oncomiR cluster [60]
Inhibition of mature microRNA 2'OME-AMOs RNA-Liposome Complex Silence OncomiR [94]
Inhibition of mature microRNA 2'MOE AMOs Oligonucleotide-Liposome Complex Silence OncomiR [95, 96]
Inhibition of pri-microRNA AMOs Oligonucleotide-Liposome Complex Silence miR cluster [97, 98]
Inhibition of mature microRNA LNA-antagomiR Unconjugated Silence OncomiR [99]
Silence selected target Synthetic microRNAs Conjugation Tumor Suppressor Function [100, 101]