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Table 3 Frequent signs and clinical symptoms ascribed to episodic unregulated release of mast cell mediators (modified from [12]; further references therein; an exhaustive survey is given in [50]).

From: Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options

Signs and Symptoms  
Abdominal abdominal pain, intestinal cramping and bloating, diarrhea and/or obstipation, nausea, non-cardiac chest pain, Helicobacter pylori-negative gastritis, malabsorption
Oropharyngeal burning pain, aphthae
Respiratory cough, asthma-like symptoms, dyspnea, rhinitis, sinusitis
Ophthalmologic conjunctivitis, difficulty in focusing
Hepatic splenomegaly, hyperbilirubinemia, elevation of liver transaminases, hypercholesterolemia
Splenomegaly  
Lymphadenopathy  
Cardiovascular tachycardia, blood pressure irregularity (hypotension and/or hypertension), syncope, hot flush
Neuropsychiatric headache, neuropathic pain, polyneuropathy, decreased attention span, difficulty in concentration, forgetfulness, anxiety, sleeplessness, organic brain syndrome, vertigo, lightheadedness, tinnitus
Cutaneous urticaria pigmentosa, hives, efflorescences with/without pruritus, telangiectasia, flushing, angioedema
Abnormal bleeding  
Musculoskeletal muscle pain, osteoporosis/osteopenia, bone pain, migratory arthritis
Interstitial cystitis  
Constitutional fatigue, asthenia, fever, environmental sensitivities