Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications

Table 1 A list of class I, class II and unclassified mutations

Class I mutations: Providing cellular proliferative and/or survival advantage	Class II mutations: Impairing cellular differentiation	Unclassified mutations:
Flt3 mutation	PML-RARα	NPM1
c-KIT mutation	AML1-ETO	Dnmt3a
N-or K-Ras mutation	CBFβ-MYH11
PTPN11	AML1 mutation
	C/EBPα mutation
	MLL-PTD