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Table 1 A list of class I, class II and unclassified mutations

From: Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications

Class I mutations: Providing cellular proliferative and/or survival advantage Class II mutations: Impairing cellular differentiation Unclassified mutations:
Flt3 mutation PML-RARα NPM1
c-KIT mutation AML1-ETO Dnmt3a
N-or K-Ras mutation CBFβ-MYH11  
PTPN11 AML1 mutation  
  C/EBPα mutation  
  MLL-PTD