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Table 1 A list of class I, class II and unclassified mutations

From: Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications

Class I mutations: Providing cellular proliferative and/or survival advantage

Class II mutations: Impairing cellular differentiation

Unclassified mutations:

Flt3 mutation

PML-RARα

NPM1

c-KIT mutation

AML1-ETO

Dnmt3a

N-or K-Ras mutation

CBFβ-MYH11

 

PTPN11

AML1 mutation

 
 

C/EBPα mutation

 
 

MLL-PTD

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