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Table 2 Inhibition of transcription factor functions by FLT3-ITD

From: Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications

Author

Target

Responsible signaling pathway

Mechanisms of the action

Mizuki et al. [43]

C/EBPα, PU.1

unknown

Down-regulates myeloid transcription factor C/EBPα and PU.1 expression.

Scheijen et al. [54]

FOXO3a

Akt

Inhibition of FOXO3a leads to the upregulation of p27KIP1 and Bim gene expression. These promote cell survival and proliferation.

Zheng et al. [55]

C/EBPα, PU.1

unknown

Down-regulates myeloid transcription factor C/EBPα and PU.1 expression. Those may play a role in myeloid differentiation block.

Radomska et al. [56]

C/EBPα

MEK/ERK

Phosphorylates serine 21 of C/EBPα, results in the differentiation block of MV4;11 cells.

Takahashi et al. [47]

PLZF

MEK/ERK

Dissociates its transcriptional co-repressor SMRT, inhibits the growth suppressor function of PLZF, leading to abnormal cell growth.

Takahashi et al. [60]

Runx1/AML1

unknown

Runx1/AML1-SMRT interaction is disrupted by FLT3-ITD, leading to the aberrant expression of the Runx1/AML1target gene p21WAF1/CIP1.