Author | Target | Responsible signaling pathway | Mechanisms of the action |
---|---|---|---|
Mizuki et al. [43] | C/EBPα, PU.1 | unknown | Down-regulates myeloid transcription factor C/EBPα and PU.1 expression. |
Scheijen et al. [54] | FOXO3a | Akt | Inhibition of FOXO3a leads to the upregulation of p27KIP1 and Bim gene expression. These promote cell survival and proliferation. |
Zheng et al. [55] | C/EBPα, PU.1 | unknown | Down-regulates myeloid transcription factor C/EBPα and PU.1 expression. Those may play a role in myeloid differentiation block. |
Radomska et al. [56] | C/EBPα | MEK/ERK | Phosphorylates serine 21 of C/EBPα, results in the differentiation block of MV4;11 cells. |
Takahashi et al. [47] | PLZF | MEK/ERK | Dissociates its transcriptional co-repressor SMRT, inhibits the growth suppressor function of PLZF, leading to abnormal cell growth. |
Takahashi et al. [60] | Runx1/AML1 | unknown | Runx1/AML1-SMRT interaction is disrupted by FLT3-ITD, leading to the aberrant expression of the Runx1/AML1target gene p21WAF1/CIP1. |