Journal of Hematology & Oncology

Table 1 Effect of G-CSFa on white blood cell counts in irradiated C57 Mice (10⁹/L; x ± SD; n = 12)

From: Effect of a structurally modified human granulocyte colony stimulating factor, G-CSFa, on leukopenia in mice and monkeys

Groups	Before Treatment	Days After Irradiation
		d5	d9	d12	d16	d19	d23	d26	d34
Control	11413 ± 2089	1233 ± 553	2450 ± 1104	2533 ± 850	3342 ± 811	5083 ± 260	7925 ± 1667	7575 ± 1858	8750 ± 2203
Wt G-CSF (50 mg/kg)	10996 ± 2731	1342 ± 337	3100 ± 1408	2667 ± 502	6358 ± 1398	9858 ± 2333^a	14650 ± 2861^b	11092 ± 2319^a	10592 ± 1547
G-CSFa (25 mg/kg)	11083 ± 2724	855 ± 342	2508 ± 923	1900 ± 972	5483 ± 973	8192 ± 2721	11192 ± 4593^a	12917 ± 2921^b	10533 ± 1741
G-CSFa (50 mg/kg)	10178 ± 4014	1100 ± 412	2042 ± 687	2508 ± 565	5325 ± 1139	9250 ± 3766^a	10975 ± 3052^a	13950 ± 3087^b	13075 ± 3120^a
G-CSFa (100 mg/kg)	11814 ± 3802	1175 ± 344	2783 ± 1233	4483 ± 1394	6325 ± 1726	13467 ± 4719^b	15650 ± 3572^b	15700 ± 4278^b	13383 ± 2696

a: p < 0.05, b: p < 0.01 vs. Control Group

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ISSN: 1756-8722

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