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Table 1 Effect of G-CSFa on white blood cell counts in irradiated C57 Mice (109/L; x ± SD; n = 12)

From: Effect of a structurally modified human granulocyte colony stimulating factor, G-CSFa, on leukopenia in mice and monkeys

Groups Before
Treatment
Days After Irradiation
   d5 d9 d12 d16 d19 d23 d26 d34
Control 11413 ± 2089 1233 ± 553 2450 ± 1104 2533 ± 850 3342 ± 811 5083 ± 260 7925 ± 1667 7575 ± 1858 8750 ± 2203
Wt G-CSF (50 mg/kg) 10996 ± 2731 1342 ± 337 3100 ± 1408 2667 ± 502 6358 ± 1398 9858 ± 2333a 14650 ± 2861b 11092 ± 2319a 10592 ± 1547
G-CSFa (25 mg/kg) 11083 ± 2724 855 ± 342 2508 ± 923 1900 ± 972 5483 ± 973 8192 ± 2721 11192 ± 4593a 12917 ± 2921b 10533 ± 1741
G-CSFa (50 mg/kg) 10178 ± 4014 1100 ± 412 2042 ± 687 2508 ± 565 5325 ± 1139 9250 ± 3766a 10975 ± 3052a 13950 ± 3087b 13075 ± 3120a
G-CSFa (100 mg/kg) 11814 ± 3802 1175 ± 344 2783 ± 1233 4483 ± 1394 6325 ± 1726 13467 ± 4719b 15650 ± 3572b 15700 ± 4278b 13383 ± 2696
  1. a: p < 0.05, b: p < 0.01 vs. Control Group