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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: Current findings for recurring mutations in acute myeloid leukemia

Figure 1

The model of the "classical" class I and class II mutations in AML. This model comprises class I mutations that activate signal transduction pathways and confer a proliferation advantage on hematopoietic cells, and class II mutations that affect transcription factors and primarily serve to impair hematopoietic differentiation [15, 16]. The development of AML is a multistep process that requires at least these two genetic abnormalities for the development of the disease. Class I mutations are shown in yellow boxes and class II mutations are in red boxes. The combination of each mutation is demonstrated as blue rings. Runx 1 mutations and MLL rearrangements may be exception in this model, as shown in orange boxes, since co-occurrence is observed between these two mutations.

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