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Table 2 Chromosomal Abnormalities in MPN and JAK2V617F-Positive Samples

From: Relevance of JAK2V617F positivity to hematological diseases - survey of samples from a clinical genetics laboratory

Diagnosis

Cases

V617F

Chromosomal Abnormalities

Ph-MPNs

1

+

Monosomy 20

 

1

+

Loss of chromosome Y

 

1

+

Isochromosome of the entire long arm of chromosome 8

 

1

-

Loss of chromosome Y

 

1

-

Chromosomes 9 and 12 translocation at 9p21 and 12p12

Leukocytosis

1

+

Deletion of the long arm of chromosome 16 at 16q23

AML

1

+

Chromosomes 8 and 21 translocation 8q22 and 21q22

 

2

+

5q deletion and monosomy 7

 

1

+

Deletion of the long arm of chromosome 5 at 5q21, deletion of the short arm of chromosome 6 at 6p21.3, and monosomy 9

Leukemia (unspecified)

1

+

Trisomy 8

 

1

+

Trisomy 20

Anemia

1

+

Trisomy 8

MDS

1

+

Deletion of the long arm of chromosome 5 at breakpoint 5q31