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Table 2 P2Y(12) receptor antagonists

From: Novel agents for anti-platelet therapy

Agents

   Mechanism of action

Administration

Main Side effects

State

Clopidogrel

   thienopyridine, blocking the effects of ADP at P2Y(12) receptor sites

Oral

bleeding, thrombocytopenia

approved

Prasugrel

   thienopyridine, blocking the effects of ADP at P2Y(12) receptor sites

Oral

bleeding

approved

Cangrelor

   nonthienopyridine, the blocking effects of ADP at P2Y(12) receptor sites

IV

bleeding

unapproved

Ticagrelor

   nonthienopyridine, the blocking effects of ADP at P2Y(12) receptor sites

Oral

bleeding

approved

  1. Abbreviations: IV: intravenous; ADP:adenosine diphosphate.