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Table 6 CR rates, ED and Cardiotoxicity rates of CAG and non-CAG induction regimens in new AML and MDS

From: A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome

Study (ref)

Disease

No. Patients

Age

Median age

Regimen

CR %

ED %

CT %

CALGB 8321 [30]

AML

326

15-83

NA

DNR (45 mg/m2) +Ara-C

61

151

NR

ECOG [7]

AML

582

17-60

48

DNR (45 mg/m2) +Ara-C

DNR (90 mg/m2) +Ara-C

57

71

4.51

5.51

7.2

7.9

SALR [5]

AML

2767

16-97

72

anthracycline + Ara-C

65

102

NR

HOVON and SAKK [31]

AML

813

60-83

67

DNR (45 mg/m2) +Ara-C

DNR (90 mg/m2) +Ara-C

54

64

112

122

NR

CAG

AML

327

18-88

NA

CAG

57

9.03

2.8

Fenaux [33]

MDS

358

38-88

69

Azacitidine

CCR

17

8

114

94

NR

Kantarjian [34]

MDS

510

17-88

63

TA/FA/CAT/IA/DA

55

175

NR

CAG

MDS

215

26-78

NA

CAG

45.7

4.83

3.1

  1. Abbreviations: AML: acute myeloid leukemia; MDS: myelodysplastic syndrome; Ref: references; NR: not reported; CR: complete remission; NA: not available; ED: early death; CT: cardiotoxicity; DNR: daunorubicin; Ara-C: cytarabine; 3+7: anthracycline plus cytarabine; CAG: cytarabine, aclarubicin and G-CSF; CCR: conventional care regimen; TA: Topotecan plus Ara-C; FA: Fludarabine plus Ara-C; CAT: Topotecan plus Ara-C plus cyclophosphamide; DA/IA: daunorubicin or idarubicin plus Ara-C; CALGB: Cancer and Leukemia Group B; ECOG: Eastern Cooperative Oncology Group; SALR: Swedish Acute Leukemia Registry; HOVON: Leukemia Working Group of the Dutch-Belgian Cooperative Trial Group for Hematology-Oncology; SAKK: Swiss Group for Clinical Cancer Research;
  2. Superscript numerical indicates the definitions of early death from different studies. 1: induction mortality (time frame not specified); 2: mortality within 30 days from diagnosis; 3: mortality within the first 8 weeks of induction treatment; 4: mortality during first 3 months; 5: mortality within 7 weeks of induction therapy.