Light chain (AL) amyloidosis: update on diagnosis and management

Table 1 Reasons to Suspect AL Amyloidosis

1.	Non-diabetic nephrotic syndrome
2.	Non-ischemic cardiomyopathy and hypertrophy*
3.	Hepatomegaly or increased alkaline phosphatase**
4.	Monoclonal gammopathy with
	a. Autonomic or sensory neuropathy
	b. Unexplained fatigue
	c. Edema
	d. Unintentional weight loss

Signs and symptoms that may represent AL amyloidosis in a patient. Non-diabetic nephrotic syndrome; non-ischemic cardiomyopathy and hypertrophy on echocardiogram, especially in the absence of hypertension*; hepatomegaly or increased alkaline phosphatase with no liver abnormalities by imaging**; or autonomic neuropathy with orthostasis or sensory neuropathy with a monoclonal protein. In patients with monoclonal gammopathy and unexplained fatigue, edema, weight loss or paresthesias, AL amyloidosis should also be considered.

ISSN: 1756-8722