Figure 4

Mice bearing NHL xenografts treated with HB22.7 treatment followed by bortezomib demonstrate reduced tumor volume and enhanced survival without increase in blood toxicity. Nude mice (n = 5 per group) were implanted with Raji xenografts and treated twice weekly (indicated by arrows) with bortezomib alone (circle), bortezomib followed by HB22.7 (square), HB22.7 followed by bortezomib (triangle), or mock-treated (diamond) as shown in Figure 1a and described in Materials and Methods. Tumor volume was measured twice weekly as described in Materials and Methods. A) Tumor volume. B) Survival.