Figure 2

The antiproliferative effect with paclitaxel and gefitinib is sequence-dependent. A. Schema of sequential treatment. B and C. The sequence of paclitaxel followed by gefitinib produced the most potent antiproliferative effect in PC-9 and Hcc827 cells. T → G, paclitaxel followed by gefitinib. G → T, gefitinib followed by paclitaxel. T + G, concomitant paclitaxel and gefitinib. T, paclitaxel alone for 72 h. G, gefitinib alone for 72 h.