Figure 3From: Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patientProfiles of concentrations of arsenic species in PB plasma collected during the remission induction therapy. Blood samples were collected before the treatment start (day -1), and 3, 7, 10, 14, 17, 21, 28, 42, 56 days after the start of administration. The concentrations of arsenic species in plasma were determined with HPLC/ICP-MS as described in "Patient and Methods." A merged representative chromatogram obtained from the analyses of a plasma sample collected on day 14 and the same plasma sample spiked with As(V), As(III), MA(V), DMA(V), and AB is shown in Figure 3(A). The signal peaks are as follows: As(V) (1), As(III) (2), MA(V) (3), DMA(V) (4), and AB (5). The concentrations of arsenic species calculated from these chromatograms are shown in Figure 3(B). (●): As(V); (■): As(III); (▲): MA(V); (♦): DMA(V); (O): AB.Back to article page