Figure 6From: Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patientTotal arsenic concentrations in HMW-F and LMW-F of PB and BM plasma. Blood samples and BM aspirations were collected before the treatment start (day -1), and 14, 28, 42, and 56 days after the start of administration. HMW-F of PB and BM plasma were prepared and subjected to total arsenic determination as described in "Patient and Methods". The total arsenic concentrations in LMW-F of PB and BM plasma were obtained by subtraction of that in HMW-F from the total arsenic concentrations in PB and BM plasma.Back to article page