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Table 3 Arsenic concentrations in PB plasma collected during the remission induction therapy

From: Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient

Days after the start of administration

-1

3

7

10

14

17

21

28

42

56

Arsenic concentrations (ngAs/g)

As(V)

0.36

0.96

0.69

0.99

1.26

1.03

1.34

1.50

0.99

0.24

 

As(III)

0

1.50

1.86

2.02

6.31

5.89

5.74

7.89

5.83

0.09

 

MA(V)

0.55

6.91

8.30

10.46

10.59

10.24

13.99

13.50

14.05

1.87

 

DMA(V)

0.11

6.14

10.3

12.2

13.2

14.0

14.0

13.3

15.3

3.96

 

AB

0.60

1.94

1.06

1.39

0.43

1.04

0.88

3.80

0.99

1.22

  1. Blood samples were collected before the treatment start (day -1), and 3, 7, 10, 14, 17, 21, 28, 42, 56 days after the start of administration. The concentrations of arsenic species in PB plasma were determined by HPLC/ICP-MS as described in "Patient and Methods".