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Table 3 Arsenic concentrations in PB plasma collected during the remission induction therapy

From: Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient

Days after the start of administration -1 3 7 10 14 17 21 28 42 56
Arsenic concentrations (ngAs/g) As(V) 0.36 0.96 0.69 0.99 1.26 1.03 1.34 1.50 0.99 0.24
  As(III) 0 1.50 1.86 2.02 6.31 5.89 5.74 7.89 5.83 0.09
  MA(V) 0.55 6.91 8.30 10.46 10.59 10.24 13.99 13.50 14.05 1.87
  DMA(V) 0.11 6.14 10.3 12.2 13.2 14.0 14.0 13.3 15.3 3.96
  AB 0.60 1.94 1.06 1.39 0.43 1.04 0.88 3.80 0.99 1.22
  1. Blood samples were collected before the treatment start (day -1), and 3, 7, 10, 14, 17, 21, 28, 42, 56 days after the start of administration. The concentrations of arsenic species in PB plasma were determined by HPLC/ICP-MS as described in "Patient and Methods".