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Table 4 Arsenic concentrations in BM plasma collected during the remission induction therapy

From: Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient

Days after the start of administration -1 14 28 42 56
Arsenic concentrations (ngAs/g) As(V) 0.35 0.54 1.91 2.34 0.17
  As(III) 0 3.43 7.47 4.00 0.10
  MA(V) 0.80 12.4 12.4 13.0 1.63
  DMA(V) 0.63 11.5 12.1 15.1 3.21
  AB 0.51 3.49 0.50 0.99 1.00
  1. BM aspirates were collected before the treatment start (day -1), and 14, 28, 42, and 56 days after the start of administration. The concentrations of arsenic species in BM plasma were determined by HPLC/ICP-MS as described in "Patient and Methods".