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Table 4 Arsenic concentrations in BM plasma collected during the remission induction therapy

From: Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient

Days after the start of administration

-1

14

28

42

56

Arsenic concentrations (ngAs/g)

As(V)

0.35

0.54

1.91

2.34

0.17

 

As(III)

0

3.43

7.47

4.00

0.10

 

MA(V)

0.80

12.4

12.4

13.0

1.63

 

DMA(V)

0.63

11.5

12.1

15.1

3.21

 

AB

0.51

3.49

0.50

0.99

1.00

  1. BM aspirates were collected before the treatment start (day -1), and 14, 28, 42, and 56 days after the start of administration. The concentrations of arsenic species in BM plasma were determined by HPLC/ICP-MS as described in "Patient and Methods".