Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient

Table 4 Arsenic concentrations in BM plasma collected during the remission induction therapy

Days after the start of administration		-1	14	28	42	56
Arsenic concentrations (ngAs/g)	As(V)	0.35	0.54	1.91	2.34	0.17
	As(III)	0	3.43	7.47	4.00	0.10
	MA(V)	0.80	12.4	12.4	13.0	1.63
	DMA(V)	0.63	11.5	12.1	15.1	3.21
	AB	0.51	3.49	0.50	0.99	1.00

BM aspirates were collected before the treatment start (day -1), and 14, 28, 42, and 56 days after the start of administration. The concentrations of arsenic species in BM plasma were determined by HPLC/ICP-MS as described in "Patient and Methods".

ISSN: 1756-8722