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Table 2 Progress in the treatment of hematologic diseases and solid tumor based on mammalian mitochondrial proteomics

From: Comparative mitochondrial proteomics: perspective in human diseases

Disease

Cell lines/Treatment

Analytical methods

Up-regulated proteins

Down-regulated proteins

Functions

Primary significance

Hematologic diseases

      

AML

NB4/camptothecin

2-DE, MALDI-TOF/TOF

 

Far upstream element-binding protein-1 (FUBP1)

transcription, translation, and degradation of proteins

Provided new insights for systematically understanding the mechanisms of the camptothecin-induced apoptosis.

    

Heterogeneous nuclear ribonucleoprotein A1 (HNRPA1)

mRNA processing

 
    

Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRPC)

modified with shift of pI and MW

 
   

26S protease regulatory subunit 6A (PSMC3)

 

degradation

 
   

Proteasome subunit alpha type (PSMA)-1, 2, 6

 

degradation

 

Non-Hodgkin's lymphoma

Raji/Adramycin

DIGE, LTQ-ESI-MS/MS

ATP synthase d chain, mitochondrial (ATPQ, ATP5H)

 

OXPHOS

Specific mitochondrial proteins were uniquely susceptible to alterations in abundance following exposure to ADR and carry implications for the investigation of therapeutic and prognostic markers.

   

Prohibitin (PHB)

 

cell cycle

 
   

Heat shock 70 kDa protein 9 precursor (HSPA9)

 

transporters and channels

 
    

Isoform 4 of Mitochondrial ATP-binding cassette sub-family B member 6 (ABCB6)

protein synthesis and degradation

 
    

Superoxide dismutase [Mn], mitochondrial precursor (SOD2)

redox

 

Other solid tumors

      

Osteosarcoma

143B/devoid of mitochondrial DNA

2-DE, MALDI-TOF/MS

 

NADH-ubiquinone oxidoreductase 75 kDa subunit

respiratory complexes subunits

Demonstrates the pleiotropic effects of mtDNA alterations and also gives valuable markers for the study of the mitochondrial-cytosolic coordination.

    

Mitochondrial 28S ribosomal protein S2

mitochondrial translation apparatus

 
    

Mitochondrial import inner membrane translocase subunit Tim9

protein transport

 
    

Succinyl-CoA ligase (ADP-forming) beta-chain

energy production

 

Breast cancer

      
 

MCF-7/resistance to adriamycin accompanied by verapamil

2-DE, QqTOF-ESI-MS/MS

 

Cofilin

control of polymerization/depolymerization of actin

Implications of the changes are considered with respect to drug resistance.

   

CoproporphyrinogenIII(CPO)

 

heme biosynthesis

 
   

3.2 trans-enoyl CoA isomerase

 

fatty acid oxidation

 
   

Adenylate kinase 2

 

ATP, OXPHOS

 

Renal cell carcinomas

      
 

UMRC2, 786-0 and RCC4/VHL (von Hippel Lindau)-defective

2-DE, MS

Heat shock 70 kDa protein

 

transporters and channels

Increased expression of septin 2 is a common event in RCC and protein modification may also alter septin 2 function in a subset of tumors.

   

10-formyltetrahydrofolate dehydrogenase

 

one-carbon metabolism

 
   

Phosphoribosylglycinamide formyltransferase

 

purine biosynthesis

 
   

Ubiquinol cytochrome c reductase complex core protein 2

 

electron transport

 
    

Elongation factor 2

protein biosynthesis

 
    

Phosphofructokinase isozyme C

glycolysis

 
    

Thioredoxin reductase

differentiation, electron transport

 
    

Septin 2

cell cycle

 

Prostate cancer

      
 

LNCaP/somatostatin

 

VDAC1, VDAC2

 

apoptosis

Somatos might be able to curb the progression of advanced prostate cancer.

    

Peroxiredoxin 2 (PRDX2)

antioxidant activity

 
    

Translationally controlled tumor protein (TCTP)

calcium binding and microtubule stabilization.

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