From: Comparative mitochondrial proteomics: perspective in human diseases
Disease | Cell lines/Treatment | Analytical methods | Up-regulated proteins | Down-regulated proteins | Functions | Primary significance |
---|---|---|---|---|---|---|
Hematologic diseases | Â | Â | Â | Â | Â | Â |
AML | NB4/camptothecin | 2-DE, MALDI-TOF/TOF | Â | Far upstream element-binding protein-1 (FUBP1) | transcription, translation, and degradation of proteins | Provided new insights for systematically understanding the mechanisms of the camptothecin-induced apoptosis. |
 |  |  |  | Heterogeneous nuclear ribonucleoprotein A1 (HNRPA1) | mRNA processing |  |
 |  |  |  | Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRPC) | modified with shift of pI and MW |  |
 |  |  | 26S protease regulatory subunit 6A (PSMC3) |  | degradation |  |
 |  |  | Proteasome subunit alpha type (PSMA)-1, 2, 6 |  | degradation |  |
Non-Hodgkin's lymphoma | Raji/Adramycin | DIGE, LTQ-ESI-MS/MS | ATP synthase d chain, mitochondrial (ATPQ, ATP5H) | Â | OXPHOS | Specific mitochondrial proteins were uniquely susceptible to alterations in abundance following exposure to ADR and carry implications for the investigation of therapeutic and prognostic markers. |
 |  |  | Prohibitin (PHB) |  | cell cycle |  |
 |  |  | Heat shock 70 kDa protein 9 precursor (HSPA9) |  | transporters and channels |  |
 |  |  |  | Isoform 4 of Mitochondrial ATP-binding cassette sub-family B member 6 (ABCB6) | protein synthesis and degradation |  |
 |  |  |  | Superoxide dismutase [Mn], mitochondrial precursor (SOD2) | redox |  |
Other solid tumors | Â | Â | Â | Â | Â | Â |
Osteosarcoma | 143B/devoid of mitochondrial DNA | 2-DE, MALDI-TOF/MS | Â | NADH-ubiquinone oxidoreductase 75 kDa subunit | respiratory complexes subunits | Demonstrates the pleiotropic effects of mtDNA alterations and also gives valuable markers for the study of the mitochondrial-cytosolic coordination. |
 |  |  |  | Mitochondrial 28S ribosomal protein S2 | mitochondrial translation apparatus |  |
 |  |  |  | Mitochondrial import inner membrane translocase subunit Tim9 | protein transport |  |
 |  |  |  | Succinyl-CoA ligase (ADP-forming) beta-chain | energy production |  |
Breast cancer | Â | Â | Â | Â | Â | Â |
 | MCF-7/resistance to adriamycin accompanied by verapamil | 2-DE, QqTOF-ESI-MS/MS |  | Cofilin | control of polymerization/depolymerization of actin | Implications of the changes are considered with respect to drug resistance. |
 |  |  | CoproporphyrinogenIII(CPO) |  | heme biosynthesis |  |
 |  |  | 3.2 trans-enoyl CoA isomerase |  | fatty acid oxidation |  |
 |  |  | Adenylate kinase 2 |  | ATP, OXPHOS |  |
Renal cell carcinomas | Â | Â | Â | Â | Â | Â |
 | UMRC2, 786-0 and RCC4/VHL (von Hippel Lindau)-defective | 2-DE, MS | Heat shock 70 kDa protein |  | transporters and channels | Increased expression of septin 2 is a common event in RCC and protein modification may also alter septin 2 function in a subset of tumors. |
 |  |  | 10-formyltetrahydrofolate dehydrogenase |  | one-carbon metabolism |  |
 |  |  | Phosphoribosylglycinamide formyltransferase |  | purine biosynthesis |  |
 |  |  | Ubiquinol cytochrome c reductase complex core protein 2 |  | electron transport |  |
 |  |  |  | Elongation factor 2 | protein biosynthesis |  |
 |  |  |  | Phosphofructokinase isozyme C | glycolysis |  |
 |  |  |  | Thioredoxin reductase | differentiation, electron transport |  |
 |  |  |  | Septin 2 | cell cycle |  |
Prostate cancer | Â | Â | Â | Â | Â | Â |
 | LNCaP/somatostatin |  | VDAC1, VDAC2 |  | apoptosis | Somatos might be able to curb the progression of advanced prostate cancer. |
 |  |  |  | Peroxiredoxin 2 (PRDX2) | antioxidant activity |  |
 |  |  |  | Translationally controlled tumor protein (TCTP) | calcium binding and microtubule stabilization. |  |