Table 1 Molecular Targets of miR-146a
From: The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer
Target Molecules | Cellular System | Biological Consequences | References |
|---|---|---|---|
TRAF6, IRAK1 (adaptor molecules downstream of Toll-like and cytokine receptors) | LPS-stimulated monocytes | Innate immunity response | Taganov et al, PNAS, [2] |
IRAK2 (adaptor molecules downstream of Toll-like and cytokine receptors) | VSV-infected macrophages | Innate immunity response | Hou et al, J Immunol [3] |
IL-8, RANTES | Lung Epithelial Alveolar Cells | Innate immunity response | Perry MM et al, J Immunol [4] |
CCL((MCP2) | HIV-infected microglial cells | Innate immunity response | Rom et al, FASEB J, [5] |
FADD | Activated T lymphocytes Jurkat cells | Anti-apoptotic effect Adaptive immune response | Curtale et al, Blood [6] |
EGF-R | Breast, pancreatic and gastric cancer | Cell proliferation, survival | Hurst et al, Cancer Res [7] Li et al, Cancer Res, [8] Kogo et al, Clin Cancer Res, [9] |
ROCK1 | Prostate cancer cells | Cell proliferation, invasion and metastasis | Lin et al, RNA, [10] |
NOTCH1 | Glioblastoma | Cell proliferation, survival and differentiation | Mei et al, Mol Cell Biol, [11] |
CXCR4 | Leukemic cell lines Hematopoietic progenitors induced to megakaryocytic differentiation Kaposi's sarcoma associated herpesvirus-infected cells | Cell migration, proliferation and differentiation | Labbaye et al, Nat Cell Biol, [12] |
KLF4 | Vascular smooth muscle cells | Vascular muscle proliferation | Sun et al, EMBO Rep, [13] |