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Table 4 Immunomodulatory effects of MSCs on immune cells

From: Clinical applications of mesenchymal stem cells

Immune cell type MSCs’ effects
T lymphocyte Suppress T cell proliferation induced by cellular or nonspecific mitogenic stimuli [44]
Alter the cytokine secretion profile of naive and effector T cells [56]
Promote the expansion and function of Treg cells [57]
B lymphocyte Inhibit proliferation of B lymphocyte [58]
Affect the chemotactic properties of B cells [59]
Suppress B-cell terminal differentiation [60]
NK cell Alter the phenotype of NK cells and suppress proliferation, cytokine secretion, and cyto-toxicity against HLA-class I- expressing targets [61, 62]
Dendritic cells (DCs) Influence differentiation, maturation and function of monocyte-derived dendritic cells [63]
  Suppress dendritic cell migration, maturation and antigen presentation [64]
  Induce mature DCs into a novel Jagged-2-dependent regulatory DC population [65]