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Table 4 Immunomodulatory effects of MSCs on immune cells

From: Clinical applications of mesenchymal stem cells

Immune cell type

MSCs’ effects

T lymphocyte

Suppress T cell proliferation induced by cellular or nonspecific mitogenic stimuli [44]

Alter the cytokine secretion profile of naive and effector T cells [56]

Promote the expansion and function of Treg cells [57]

B lymphocyte

Inhibit proliferation of B lymphocyte [58]

Affect the chemotactic properties of B cells [59]

Suppress B-cell terminal differentiation [60]

NK cell

Alter the phenotype of NK cells and suppress proliferation, cytokine secretion, and cyto-toxicity against HLA-class I- expressing targets [61, 62]

Dendritic cells (DCs)

Influence differentiation, maturation and function of monocyte-derived dendritic cells [63]

 

Suppress dendritic cell migration, maturation and antigen presentation [64]

 

Induce mature DCs into a novel Jagged-2-dependent regulatory DC population [65]