Figure 1

Lower level of PU.1 mRNA expression in de novo APL patients in comparison to normal hematopoietic cells. The relative PU.1 expression, as compared to that of the reference gene GAPDH, in leukemic cells freshly isolated from APL samples (Table 1), normal peripheral blood cells (WBCs, MNCs, and granulocytes) and CD34⁺ cells from human UCB specimens was determined using real-time RT-PCR. Each symbol represents the average value from an individual patient or healthy subject, and the lines indicate the median value.