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Table 1 Patient characteristics in the imatinib and non-imatinib groups

From: Administration of imatinib after allogeneic hematopoietic stem cell transplantation may improve disease-free survival for patients with Philadelphia chromosome-positive acute lymphobla stic leukemia

 

Imatinib group

Non-imatinib group

P-value

Number of patients

62(75.6%)

20(24.4%)

 

Age (y), median (range)

29(6-50)

27.5(3-51)

0.256

<30 / >30 y

37/25

10/10

0.604

Sex (M/F)

43/19

12/8

0.071

Disease status pre-HCT

   

CR1/ >CR1

50/12

16/4

1.000

Additional cytogenetic

   

abnormality

   

Yes/No

3/59

1/19

0.272

Imatinib therapy before HCT

   

Yes/ No

54/8

14/6

0.180

RT-PCR-BCR/ABL(pre-HCT)

   

0/ >0

26/36

6/14

0.752

Donor type

   

HLA matched siblings

15

4

0.199

MMR

45

15

 

MUD

2

1

 

Stem-cell source

   

PBSCT

7

2

1.000

BMT + PBSCT

55

18

 

Conditioning regimen

   

BUCY

62

17

0.013

TBI/CY

0

3

 

Engraftment

   

Myeloid (day),median(range)

13(10-22)

13(10-27)

0.248

Platelet (day),median(range)

17(9-150)

13(7-30)

0.268

RT-PCR-BCR/ABL(post-HCT)

   

0/ >0

48/ 14

18/ 2

0.540

Acute GVHD

   

0/ I°-II°/ III-IV°

30/ 28/ 4

5/ 11/ 4

0.199

Chronic GVHD

   

no/ L/ E-cGVHD

22/ 25/ 12

3/ 8/ 8

0.223

  1. CR1, first complete remission; MMR, mismatched related; MUD, matched unrelated donor; BMT, bone marrow transplant; PBSCT, peripheral blood stem cell transplant; L, local; E-cGVHD, extensive chronic GVHD.