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Table 4 Diagnosis performance of hnRNP K and serum AFP as biomarker panel for detection of early HCC

From: Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a tissue biomarker for detection of early Hepatocellular carcinoma in patients with cirrhosis

Test features Parallel test Serial test
  hnRNP K ≥7.160 ppm
o AFP ≥ 100 ng/mL
hnRNP K ≥7.160 ppm
or AFP ≥ 400 ng/mL
hnRNP KL ≥7.160 ppm
and op AFP ≥ 100 ng/mL
hnRNP K ≥7.160 ppm
and AFP ≥ 400 ng/mL
Sensitivity (Sen) 93.33 % 93.33 % 33.33 % 33.33 %
Specificity (Spe) 44.00 % 32.00 % 96.00 % 92.00 %
False negative rate (FNR) 0.0667 0.0667 0.6667 0.6667
False positive rate (FPR) 0.5600 0.6800 0.0400 0.0800
Youden index 0.3733 0.2533 0.2933 0.2533
Positive predictive value (PPV) 0.5000 0.4516 0.8333 0.7143
Negative predictive value (NPV) 0.9167 0.8889 0.7059 0.6970
Accuracy 0.6250 0.5500 0.7250 0.7000