Table 1 Mutation analysis in the cohort of LEN patients
Case | Response | TET2 | UTX | CBL | EZH2 | ASXL1 | TP53 | N-RAS | K-RAS | IDH1 | IDH2 | DNMT3A |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CR | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
2 | CR | WT | WT | WT | WT | L775fsX1 | WT | WT | WT | WT | WT | WT |
3 | PR | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
4 | NR | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
5 | CR | WT | WT | WT | WT | E1102D | WT | WT | WT | WT | WT | R882H |
6 | PR | P1681fsX2 | WT | WT | WT | P1277fsX2 | WT | WT | WT | WT | WT | WT |
7 | CR | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
8 | HI | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
10 | CR | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
11 | HI | WT | WT | WT | WT | WT | WT | WT | L19F | WT | WT | WT |
12 | CR | V1417F | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
13 | NR | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
14 | PR | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
15 | CR | T1978P | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
16 | NR | WT | WT | WT | WT | S846N | WT | WT | WT | WT | WT | WT |
17 | NR | N1068fsX13 | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
18 | NR | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
19 | NR | P1962L | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |
20 | CR | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | R882H |
21 | HI | WT | WT | WT | T726X | WT | WT | WT | WT | WT | WT | WT |
22 | HI | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT | WT |