Table 4 Patients characteristics who received LEN without del[5q] by MC (N = 42)

1

73

M

RAEB-2

INT-2

LEN/AZA

CR

N

N

Gain

4q13.2

2

75

M

RAEB-1

INT-1

LEN/AZA

CR

N

trisomy 8

9%

Gain

8q11.1q11.21

UPD

11q14.1q21

3

62

M

MDS/MP N-U

INT-1

LEN/AZA

PR

N

N

UPD

1pterp32.3

UPD

3p21.31p21.1

4

68

M

RAEB-2

HIGH

LEN/AZA

NR

complex karyotype, including trisomy 8, del[7q], del[12], and del[20]

del[7q]

68%

Gain

8

del[20q]

60%

Loss

11p14.3p13

trisomy 8

41%

Loss

12p12.3p11.21

Loss

12q21.1q21.31

Loss

16q22.3q24.3

Loss

1p22.2p22.1

Loss

20q11.2q13.33

Loss

21q11.2q21.1

Loss

2q31.3q32.1

Loss

6q23.3

Gain

7q11.21q11.22

Loss

7q22.1q36.2

5

68

M

RAEB-2

INT-2

LEN/AZA

CR

47,XY,+8[6]

trisomy 8

9%

Gain

14q11.1q11.2

UPD

19p13.11p12

Gain

8p23.3q24.3

6

73

M

CMML-1

NE

LEN

PR

N

del[20q]

10%

UPD

9pterp22.2

7

67

M

PMF

NE

LEN

PR

N

N

Loss

11q23.3

8

66

M

RCMD

LOW

LEN

HI

46,XY,del(20)(q11q13)[2]/4 6,XY[18]

del[20q]

17%

Gain

8q11.1q11.23

9

69

M

RAEB-1

INT-2

LEN/AZA

CR

N

N

NE

10

64

M

MDS/MP N-U

NE

LEN

CR

N

N

N

11

79

F

CMML-2

NE

LEN/AZA

HI

47,XX,+8[20]

trisomy 8

42%

Gain

8

12

62

F

RAEB-2

INT-2

LEN/AZA

CR

N

N

N

13

62

F

RARS

INT-1

LEN

NR

46,XX,add(15)(p11.1),add(2 2)(p11.2)[3]/47,idem,+19[19].

del[7q]

11%

Gain

19

del[7]

6%

Gain

3q26.1

Gain

4p16.2

14

72

M

MDS/MPN-U

INT-2

LEN

PR

no growth

del[5q]

8%

Loss

20q11.1q13.12

del[20q]

35%

Loss

2p21p24.1

Loss

8q11.23q12.1

Gain

9p12pter

15

63

M

RAEB-2

NE

LEN/AZA

CR

N

N

Gain

12q24.32

Gain

8q11.1

16

81

F

RAEB-2

INT-2

LEN/AZA

NR

N

N

N

17

69

M

CMML-2

-

LEN/AZA

NR

N

NE

Loss

2p22.3

18

46

M

PMF

-

LEN

NR

balanced translocation at chromosomes 2 and 22

NE

UPD

14q31.3q32.33

Gain

9p24.3p11.1

19

70

F

sAML

-

LEN (High dose)

NR

N

del[5q]

33%

Loss

5q31.2

20

65

F

RARS

LOW

LEN

CR

N

NE

N

21

70

M

CMML-1

INT-1

LEN

HI

N

N

UPD

7q22.1qter

22

83

M

RARS

LOW

LEN

HI

N

N

N

23

83

M

RARS

INT-1

LEN

NR

N

NE

N

24

71

M

MDS-U

INT-1

LEN

NE

N

NE

Loss

15q14

25

69

M

RARS

LOW

LEN

NR

N

NE

N

26

76

M

RA

INT-1

LEN

NR

N

NE

Loss

3p22.3

27

68

M

RA

INT-1

LEN

NR

N

NE

Loss

21q21.2

Gain

3p14.1

Loss

11q14.3

28

59

M

RARS

LOW

LEN

NR

N

NE

N

29

73

F

RA

LOW

LEN

NR

N

NE

N

30

78

F

RARS

LOW

LEN

NE

N

NE

UPD

3q21.3qter

31

78

M

RAEB-1

INT-2

LEN

NR

47,XY,+19

NE

Gain

19

32

80

M

RAEB-1

INT-1

LEN

NE

N

NE

Loss

17q11.2

UPD

8p11.2qter

33

79

F

RARS

INT-1

LEN

HI

N

NE

N

34

73

F

RARS

LOW

LEN

HI

N

NE

Loss

18p11.32

35

78

F

sAML

-

LEN

NR

46,XX,t(3;3)

NE

Loss

3q26.1

36

80

M

RAEB-2

INT-2

LEN

NR

N

NE

Loss

22q13.2

37

69

M

RARS

LOW

LEN

HI

N

NE

N

38

59

F

RA

LOW

LEN

HI

N

NE

N

39

62

F

RARS

LOW

LEN

NE

N

NE

Gain

6p21.32

40

82

M

RARS

INT-1

LEN

NR

46,XY,del(20)(q11.2)

NE

Loss

20q11.2q13.2

41

53

M

RARS

LOW

LEN

HI

N

NE

N

42

56

F

RA

INT-1

LEN

HI

N

NE

Loss

9p21.2

Gain

1p21.1