Table 1 Characteristics of 18 sHLH patients
From: The significance of 18F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis
No. | Age/ Sex | Underlying disease | Therapy | Outcome | Survival (month) | Organs | SUVmax |
|---|---|---|---|---|---|---|---|
1 | 35/M | Lymphoma (NK / T) | IVIG/HLH-2004 regimen(1 cycle) → High-dose methylprednisolone pulse therapy | Died of intracranial hemorrhage | 1.7 | 6 | 12.3 |
2 | 35/F | Lymphoma (NK / T) | The Hyper-CVAD regimen (1 cycle) | Died of intracranial hemorrhage | 1.2 | 6 | 15.7 |
3 | 18/M | Lymphoma (NK / T) | The CHOP regimen(1 cycle) | Died of acute hemorrhage of gastrointestinal tract | 0.3 | 7 | 14.6 |
4 | 56/M | Lymphoma | Hydrocortisone 100mg×5d | Died of intracranial hemorrhage | 1.7 | 5 | 4.3 |
5 | 32/M | Lymphoma | Dex 10mg/d×3d | Died of liver failure | 0.3 | 10 | 13.3 |
6 | 37/F | Sjögren's syndrome | The COP regimen(3 cycle) | CR | >12 | 5 | 0.7 |
7 | 15/F | UCTD | The COP regimen (4 cycle) | CR | >45 | 3 | 4.6 |
8 | 21/F | EBV infection | HLH-2004 regimen (1 cycle) | Died of acute hemorrhage of gastrointestinal tract | 1.7 | 7 | 6.6 |
9 | 17/M | EBV infection | Methylprednisolone 40 mg/d×24d | CR | >22 | 7 | 8.3 |
10 | 46/M | EBV infection | Dex 15mg/d×4d | Died of septic shock | 0.4 | 6 | 10 |
11 | 73/M | EBV infection | The COP regimen (7 cycle) | Died of multi-organ failure | 6 | 7 | 5.2 |
12 | 26/F | CMV infection | IVIG/HLH-2004 regimen (1 cycle) →The CHOP regimen(2 cycle) | CR | >24 | 6 | 9 |
13 | 24/F | CMV infection | The COP regimen (7 cycle) | Died of respiratory failure | 2.2 | 5 | 4.2 |
14 | 69/F | MRSH infection | The COP regimen (2 cycle) | Died of respiratory failure | 2.0 | 6 | 5.2 |
15 | 62/F | Fungal Infection | The COP regimen (7 cycle) | stable | >8 | 4 | 5.8 |
16 | 44/F | Malignant tumour? | Methylprednisolone 40 mg/d×5d | Died of multi-organ failure | 0.4 | 8 | 7.7 |
17 | 56/M | Lymphoma? | The CHOP regimen (2 cycle) →Splenectomy→The Hyper-CVAD regimen (1cycle) | stable | >13 | 6 | 5.7 |
18 | 18/M | indefinite | HLH-2004 regimen (1 cycle) | Died of intracranial hemorrhage | 0.2 | 3 | 4.2 |