From: Molecular functions of metallothionein and its role in hematological malignancies
Lineage | Cells | Role | Ref. |
---|---|---|---|
Undetermined | ES-derived differentiated cells | Overexpression of MT-I gene prevents LIF withdrawal induced apoptosis in ES derived differentiated cells | [64] |
Undetermined | human cord blood cells | MT is more highly expressed in mature CD34– cells than in immature CD34+ cells | [67] |
Megakaryocyte | Megakaryocytic DAMI cells | Overexpression of MT-IIA resulted in the increase of cell size, intracellular granulation and increment of the megakaryocytic specific CD41 and CD42 and arresting in cell proliferation | [68] |
Megakaryocyte, erythroid | K562, DAMI, MEG-01, ELF-153 | The more mature K562, DAMI, and MEG-01 cell lines exhibited transcription of all MT isogenes, except MT-III and MT-IV. | [65] |
Phorbol ester induces increased MT transcription and biosynthesis. | Â | ||
Erythroid | K562 cells | EPO- or sodium butyrate-induced differentiation as monitored by hemoglobin formation was inhibited in K562 cells stably transfected with an expression vector containing human MT-IIA gene. | [70] |
Erythroid | Rat (acute blood loss, phenylhydrazine induced anemia model) | Induced erythropoiesis or anemia in rats, the induction of MT in the bone marrow is enhanced, with predominant accumulation in erythroblasts | [69] |
T lymphoid | T cell line CCRF-CEM | Inhibition of hMTs synthesis by ODNs stimulated the apoptotic process | [71] |