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Table 1 Roles of MT in hematopoietic cells

From: Molecular functions of metallothionein and its role in hematological malignancies

Lineage

Cells

Role

Ref.

Undetermined

ES-derived differentiated cells

Overexpression of MT-I gene prevents LIF withdrawal induced apoptosis in ES derived differentiated cells

[64]

Undetermined

human cord blood cells

MT is more highly expressed in mature CD34– cells than in immature CD34+ cells

[67]

Megakaryocyte

Megakaryocytic DAMI cells

Overexpression of MT-IIA resulted in the increase of cell size, intracellular granulation and increment of the megakaryocytic specific CD41 and CD42 and arresting in cell proliferation

[68]

Megakaryocyte, erythroid

K562, DAMI, MEG-01, ELF-153

The more mature K562, DAMI, and MEG-01 cell lines exhibited transcription of all MT isogenes, except MT-III and MT-IV.

[65]

Phorbol ester induces increased MT transcription and biosynthesis.

 

Erythroid

K562 cells

EPO- or sodium butyrate-induced differentiation as monitored by hemoglobin formation was inhibited in K562 cells stably transfected with an expression vector containing human MT-IIA gene.

[70]

Erythroid

Rat (acute blood loss, phenylhydrazine induced anemia model)

Induced erythropoiesis or anemia in rats, the induction of MT in the bone marrow is enhanced, with predominant accumulation in erythroblasts

[69]

T lymphoid

T cell line CCRF-CEM

Inhibition of hMTs synthesis by ODNs stimulated the apoptotic process

[71]