Figure 1
The mRNA levels of SRSF1 and PRMT1 are dramatically up-regulated in pediatric ALL cases. (A) Heat map of the mRNA level of SFRS1 (black arrow). The fold changes of the differential expressions compared with the control were indicated by the color intensity with red representing up-regulation. HD, hyperdiploid > 50 chromosomes. (B) The mRNA level of SFRS1 was measured by RT-PCR in paired cDNA samples from 10 ALL patients (n = 20). Each paired sample refers to two samples from one patient at the time of ND and CR, respectively. The SFRS1 mRNA level was higher in the ND samples compared to the CR samples (fold change 2.53, p = 0.000, Paired Samples T test). (C) The mRNA level of PRMT1 was measured by RT-PCR in paired cDNA samples from 10 ALL patients. The PRMT1 mRNA level was dramatically higher in the ND samples compared to CR samples (fold change 4.95, p = 0.000, Paired Samples T test). ND, newly diagnosed. CR, complete remission.