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Table 2 Univariate and multivariate analyses of risk factors for EBV and CMV infections after allo-HSCT

From: Effects of intensified conditioning on Epstein-Barr virus and cytomegalovirus infections in allogeneic hematopoietic stem cell transplantation for hematological malignancies

Risk factors EBV viremia EBV-associated diseases CMV viremia CMV-associated diseases
  Univariate Multivariate (RR) Univariate Multivariate (RR) Univariate Multivariate (RR) Univariate Multivariate (RR)
male vs female NS NS NS NS NS NS NS NS
Age, <20 years vs ≥20 to ≤ 40 years vs > 40 years NS NS NS NS NS NS NS NS
Disease status, CR vs NR P = 0.029 NS NS NS NS NS NS NS
Related vs unrelated donor P<0.001 NS P<0.001 NS NS NS NS NS
HLA typing, matched vs mismatched P<0.001 NS P<0.001 NS P<0.001 P<0.001 (2.441) NS NS
Standard vs intensified conditioning P = 0.002 P = 0.037 (1.759) P = 0.006 P = 0.037 (2.290) NS NS NS NS
EBV serological matches vs mismatches NS NS NS NS NS NS NS NS
CMV serological matches vs mismatches NS NS NS NS NS NS NS NS
ATG vs no ATG P<0.001 P<0.001 (15.554) P<0.001 P<0.001 (19.216) P<0.001 NS P = 0.006 NS
Flu vs no Flu NS NS NS NS NS NS NS NS
Acute GVHD II-IV vs 0-I NS NS P = 0.032 NS P<0.001 NS P = 0.002 P = 0.017 (12.554)
Chronic GVHD vs no cGVHD NS NS NS NS NS NS NS NS
Early CsA withdrawal vs no early withdrawal NS NS NS NS P<0.001 P = 0.002 (2.112) NS NS
DLI vs no DLI NS NS NS NS P = 0.010 NS NS NS
  1. RR = relative risk; vs = versus; CR = complete remission; NR = not in CR; HLA = human leukocyte antigen; EBV = Epstein-Barr virus; CMV = Cytomegalovirus; ATG = anti-thymocyte globulin; FLU = fludarabine; GVHD = graft-versus-host disease; CSA = cyclosporine A; DLI = donor lymphocyte infusion; NS = not significant.