Effects of intensified conditioning on Epstein-Barr virus and cytomegalovirus infections in allogeneic hematopoietic stem cell transplantation for hematological malignancies

Table 2 Univariate and multivariate analyses of risk factors for EBV and CMV infections after allo-HSCT

Risk factors	EBV viremia		EBV-associated diseases		CMV viremia		CMV-associated diseases
	Univariate	Multivariate (RR)	Univariate	Multivariate (RR)	Univariate	Multivariate (RR)	Univariate	Multivariate (RR)
male vs female	NS	NS	NS	NS	NS	NS	NS	NS
Age, <20 years vs ≥20 to ≤ 40 years vs > 40 years	NS	NS	NS	NS	NS	NS	NS	NS
Disease status, CR vs NR	P = 0.029	NS	NS	NS	NS	NS	NS	NS
Related vs unrelated donor	P<0.001	NS	P<0.001	NS	NS	NS	NS	NS
HLA typing, matched vs mismatched	P<0.001	NS	P<0.001	NS	P<0.001	P<0.001 (2.441)	NS	NS
Standard vs intensified conditioning	P = 0.002	P = 0.037 (1.759)	P = 0.006	P = 0.037 (2.290)	NS	NS	NS	NS
EBV serological matches vs mismatches	NS	NS	NS	NS	NS	NS	NS	NS
CMV serological matches vs mismatches	NS	NS	NS	NS	NS	NS	NS	NS
ATG vs no ATG	P<0.001	P<0.001 (15.554)	P<0.001	P<0.001 (19.216)	P<0.001	NS	P = 0.006	NS
Flu vs no Flu	NS	NS	NS	NS	NS	NS	NS	NS
Acute GVHD II-IV vs 0-I	NS	NS	P = 0.032	NS	P<0.001	NS	P = 0.002	P = 0.017 (12.554)
Chronic GVHD vs no cGVHD	NS	NS	NS	NS	NS	NS	NS	NS
Early CsA withdrawal vs no early withdrawal	NS	NS	NS	NS	P<0.001	P = 0.002 (2.112)	NS	NS
DLI vs no DLI	NS	NS	NS	NS	P = 0.010	NS	NS	NS

RR = relative risk; vs = versus; CR = complete remission; NR = not in CR; HLA = human leukocyte antigen; EBV = Epstein-Barr virus; CMV = Cytomegalovirus; ATG = anti-thymocyte globulin; FLU = fludarabine; GVHD = graft-versus-host disease; CSA = cyclosporine A; DLI = donor lymphocyte infusion; NS = not significant.

ISSN: 1756-8722