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Table 1 Type of IDH1 and IDH2 mutations identified in 230 AML patients

From: Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

Mutation

Nucleotide change

Predicted protein change

No. of patients

IDH1*

   

   c.G395A

CGT-CAT

p.R132H

8

   c.C394T

CGT-TGT

p.R132C

6

   c.C394A

CGT-AGT

p.R132S

2

   c.C394G

CGT-GGT

p.R132G

2

   c.G395T

CGT-CTT

p.R132L

1

   c.A297G

ATA-ATG

p.I99M

1

IDH2**

   

   c.G419A

CGG-CAG

p.R140Q

20

   c.G515A

AGG-AAG

p.R172K

4

  1. Abbreviation: AML, acute myeloid leukemia; C, cysteine; G, glycine; H, histidine; I, isoleucine; K, lysine; L, leucine; M, methionine; Q, glutamine; S, serine
  2. *IDH1 nucleotide numbering based upon the National Center for Biotechnology Information sequence NM_005896.2
  3. **IDH2 nucleotide numbering based upon the National Center for Biotechnology Information sequence NM_002168.2
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Journal of Hematology & Oncology

ISSN: 1756-8722

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